Micafungin concentrations in the plasma and burn eschar of severely burned patients

Junichi Sasaki, Satoshi Yamanouchi, Daisuke Kudo, Tomoyuki Endo, Ryosuke Nomura, Kiyotsugu Takuma, Shigeki Kushimoto, Yotaro Shinozawa, Satoshi Kishino, Shingo Hori, Naoki Aikawa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC90s of micafungin against clinically important Candida and Aspergillus species.

Original languageEnglish
Pages (from-to)1113-1115
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Sasaki, J., Yamanouchi, S., Kudo, D., Endo, T., Nomura, R., Takuma, K., Kushimoto, S., Shinozawa, Y., Kishino, S., Hori, S., & Aikawa, N. (2012). Micafungin concentrations in the plasma and burn eschar of severely burned patients. Antimicrobial Agents and Chemotherapy, 56(2), 1113-1115. https://doi.org/10.1128/AAC.05381-11