Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

Kenji Miyamoto, Shigeo Tsuchiya, Hiromichi Ohta

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

α-Methyl-α-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active α-arylpropionic acids. Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing. Decarboxylation of α-fluoro-α- phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro- α-phenylacetic acid.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalJournal of Fluorine Chemistry
Volume59
Issue number2
DOIs
Publication statusPublished - 1992 Nov

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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