Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

Kenji Miyamoto, Shigeo Tsuchiya, Hiromichi Ohta

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

α-Methyl-α-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active α-arylpropionic acids. Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing. Decarboxylation of α-fluoro-α- phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro- α-phenylacetic acid.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalJournal of Fluorine Chemistry
Volume59
Issue number2
DOIs
Publication statusPublished - 1992

Fingerprint

Alcaligenes
decarboxylation
Decarboxylation
Fluorine
fluorine
Reaction products
Bacteria
Electrons
Derivatives
acids
Acids
acid
reaction products
bacteria
electron
bacterium
phenylacetic acid
malonic acid
phenylmalonic acid
rings

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives. / Miyamoto, Kenji; Tsuchiya, Shigeo; Ohta, Hiromichi.

In: Journal of Fluorine Chemistry, Vol. 59, No. 2, 1992, p. 225-232.

Research output: Contribution to journalArticle

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