Microbial asymmetric reduction of α-hydroxyketones in the anti-Prelog selectivity

Toshikuni Tsujigami, Takeshi Sugai, Hiromichi Ohta

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46 Citations (Scopus)

Abstract

Yamadazyma farinosa IFO 10896 was found to reduce α-hydroxyketones bearing a phenyl ring to give optically active diols with anti-Prelog selectivity. The distance between the carbonyl group and the phenyl ring was shown to have an interesting effect on the reactivity and selectivity of the enzyme system.

Original languageEnglish
Pages (from-to)2543-2549
Number of pages7
JournalTetrahedron Asymmetry
Volume12
Issue number18
DOIs
Publication statusPublished - 2001 Oct 15

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ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

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