Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya, Naoko Sakai, Takeshi Sugai, Hiromichi Ohta

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111 Citations (Scopus)


Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

Original languageEnglish
Pages (from-to)1343-1346
Number of pages4
JournalTetrahedron Letters
Issue number10
Publication statusPublished - 1991 Mar 4


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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