Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya, Naoko Sakai, Takeshi Sugai, Hiromichi Ohta

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

Original languageEnglish
Pages (from-to)1343-1346
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number10
DOIs
Publication statusPublished - 1991 Mar 4

Fingerprint

Nitriles
Carboxylic Acids
Amides
Hydrolysis
Rhodococcus
Enzyme kinetics
Enzymatic hydrolysis
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids. / Kakeya, Hideaki; Sakai, Naoko; Sugai, Takeshi; Ohta, Hiromichi.

In: Tetrahedron Letters, Vol. 32, No. 10, 04.03.1991, p. 1343-1346.

Research output: Contribution to journalArticle

@article{0e74847bea10494287a31f21dcb44a30,
title = "Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids",
abstract = "Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.",
author = "Hideaki Kakeya and Naoko Sakai and Takeshi Sugai and Hiromichi Ohta",
year = "1991",
month = "3",
day = "4",
doi = "10.1016/S0040-4039(00)79663-8",
language = "English",
volume = "32",
pages = "1343--1346",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

AU - Kakeya, Hideaki

AU - Sakai, Naoko

AU - Sugai, Takeshi

AU - Ohta, Hiromichi

PY - 1991/3/4

Y1 - 1991/3/4

N2 - Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

AB - Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

UR - http://www.scopus.com/inward/record.url?scp=0026021192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026021192&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)79663-8

DO - 10.1016/S0040-4039(00)79663-8

M3 - Article

VL - 32

SP - 1343

EP - 1346

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 10

ER -