Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya; Naoko Sakai; Takeshi Sugai; Hiromichi Ohta

doi:10.1016/S0040-4039(00)79663-8

Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya, Naoko Sakai, Takeshi Sugai, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

112 Citations (Scopus)

Abstract

Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

Original language	English
Pages (from-to)	1343-1346
Number of pages	4
Journal	Tetrahedron Letters
Volume	32
Issue number	10
DOIs	https://doi.org/10.1016/S0040-4039(00)79663-8
Publication status	Published - 1991 Mar 4

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)79663-8

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abstract = "Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.",

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AU - Ohta, Hiromichi

PY - 1991/3/4

Y1 - 1991/3/4

N2 - Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

AB - Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

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Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Abstract

ASJC Scopus subject areas

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