Microbiological Profile of Septic Complication in Patients With Cardiogenic Shock Following Acute Myocardial Infarction (from the SHOCK Study)

Shun Kosaka, Venu Menon, Kentaro Iwata, April Lowe, Lynn A. Sleeper, Judith S. Hochman

Research output: Contribution to journalArticle

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Abstract

We sought to assess the microbiologic profile of patients with suspected sepsis who participated in the SHould we emergently revascularize Occluded Coronaries in cardiogenic shocK? (SHOCK) trial, a randomized controlled trial of early coronary revascularization in patients with cardiogenic shock complicating acute myocardial infarction. A protocol-mandated SEPSIS form was completed prospectively for 54 patients (18%) with fever or leukocytosis suggestive of sepsis. These patients were divided further into those with positive (n = 40) or negative (n = 14) culture results. The predominant pathogen isolated in patients with positive culture results was Staphylococcus aureus (32%), followed by Klebsiella pneumoniae and Pseudomonas aeruginosa. Patients with both positive and negative culture results had longer median durations of mechanical ventilation (p <0.001 and p = 0.02), intra-aortic balloon pump (IABP) support (p = 0.074 and p = 0.021), and hospital stay (p <0.001 and p = 0.048) than controls. Sepsis was predicted by both duration of IABP support (p = 0.007) and use of multiple central catheters (p = 0.026). In conclusion, clinical sepsis is common after cardiogenic shock complicating acute myocardial infarction, particularly in patients who received prolonged IABP support or had multiple central catheters.

Original languageEnglish
Pages (from-to)802-804
Number of pages3
JournalAmerican Journal of Cardiology
Volume99
Issue number6
DOIs
Publication statusPublished - 2007 Mar 15
Externally publishedYes

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Cardiogenic Shock
Myocardial Infarction
Sepsis
Catheters
Leukocytosis
Klebsiella pneumoniae
Artificial Respiration
Pseudomonas aeruginosa
Staphylococcus aureus
Length of Stay
Fever
Randomized Controlled Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Microbiological Profile of Septic Complication in Patients With Cardiogenic Shock Following Acute Myocardial Infarction (from the SHOCK Study). / Kosaka, Shun; Menon, Venu; Iwata, Kentaro; Lowe, April; Sleeper, Lynn A.; Hochman, Judith S.

In: American Journal of Cardiology, Vol. 99, No. 6, 15.03.2007, p. 802-804.

Research output: Contribution to journalArticle

Kosaka, Shun ; Menon, Venu ; Iwata, Kentaro ; Lowe, April ; Sleeper, Lynn A. ; Hochman, Judith S. / Microbiological Profile of Septic Complication in Patients With Cardiogenic Shock Following Acute Myocardial Infarction (from the SHOCK Study). In: American Journal of Cardiology. 2007 ; Vol. 99, No. 6. pp. 802-804.
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