Microbiota in autoimmunity and tolerance

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The composition of a host's intestinal microbiota directs the type of mucosal and systemic immune responses by affecting the proportion and number of functionally distinct T cell subsets. In particular, the microbiota composition affects the differentiation of intestinal Th17 cells and Foxp3 + regulatory T cells, both of which play critical roles in maintaining mucosal barrier functions and in controlling immunological homeostasis. In this review, we discuss the recent advances in our understanding of how the intestinal microbiota affects T cell differentiation and host susceptibility to autoimmune disease.

Original languageEnglish
Pages (from-to)761-768
Number of pages8
JournalCurrent Opinion in Immunology
Volume23
Issue number6
DOIs
Publication statusPublished - 2011 Dec
Externally publishedYes

Fingerprint

Microbiota
Autoimmunity
Th17 Cells
Mucosal Immunity
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Autoimmune Diseases
Cell Differentiation
Homeostasis
T-Lymphocytes
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Microbiota in autoimmunity and tolerance. / Atarashi, Koji; Honda, Kenya.

In: Current Opinion in Immunology, Vol. 23, No. 6, 12.2011, p. 761-768.

Research output: Contribution to journalArticle

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