Microbiotal influence on T cell subset development

Koji Atarashi, Yoshinori Umesaki, Kenya Honda

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

The mammalian alimentary tract harbors hundreds of bacterial species that constitute the indigenous microbial flora. The indigenous microbial flora has long been appreciated for its role in host immune system development. Recent reports suggest that components of the microbial flora differentially affect the proportion and number of functionally distinct subsets of T cells in the intestine. Substantial changes in the composition of the microbiota are associated with inflammatory bowel disease. This review will discuss the importance of individual species of microbial flora in the induction of T cell subsets, particularly Th17 cells and regulatory T (Treg) cells in the intestine.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalSeminars in Immunology
Volume23
Issue number2
DOIs
Publication statusPublished - 2011 Apr

Keywords

  • Microbial flora
  • Segmented filamentous bacteria
  • Th17
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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