Microelectrospray interface with coaxial sheath flow for high-resolution capillary electrophoresis/mass spectrometry separation

Masahiko Hashimoto, Yasushi Ishihama, Masaru Tomita, Tomoyoshi Soga

Research output: Contribution to journalArticle

13 Citations (Scopus)


We have fabricated a coaxial sheath liquid flow microelectrospray ionization (μESI) interface for capillary electrophoresis coupled with mass spectrometry (CE/MS). The ESI interface, which features a reduced probe diameter (130 μm i.d. x 174 μm o.d.) with a nebulizer-free format, can relatively easily electrospray a large amount of make-up sheath liquid (5-10 μL/min) over the long term (more than 80 runs) with a high degree of stability. The interface also provides higher separation qualities and improved detection sensitivities compared with a conventional ion spray (IS) interface.

Original languageEnglish
Pages (from-to)3579-3584
Number of pages6
JournalRapid Communications in Mass Spectrometry
Issue number22
Publication statusPublished - 2007 Nov 23


ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

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