Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment

Takao Yasui; Jumpei Morikawa; Noritada Kaji; Manabu Tokeshi; Kazuo Tsubota; Yoshinobu Baba

doi:10.3390/mi7070113

Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment

Takao Yasui, Jumpei Morikawa, Noritada Kaji, Manabu Tokeshi, Kazuo Tsubota, Yoshinobu Baba

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

Original language	English
Article number	113
Journal	Micromachines
Volume	7
Issue number	7
DOIs	https://doi.org/10.3390/mi7070113
Publication status	Published - 2016 Jul 4

Keywords

Autologous serum eye-drops
Dry eye
Spiral microchannel

ASJC Scopus subject areas

Control and Systems Engineering
Mechanical Engineering
Electrical and Electronic Engineering

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10.3390/mi7070113

Cite this

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title = "Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment",

abstract = "Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.",

keywords = "Autologous serum eye-drops, Dry eye, Spiral microchannel",

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doi = "10.3390/mi7070113",

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AU - Yasui, Takao

AU - Morikawa, Jumpei

AU - Kaji, Noritada

AU - Tokeshi, Manabu

AU - Tsubota, Kazuo

AU - Baba, Yoshinobu

N1 - Funding Information: This research was supported by the JSPS Grant-in-Aid for Scientific Research (A) 16H02091, Nanotechnology Platform Program (Molecule and Material Synthesis) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), and PRESTO, JST. Publisher Copyright: © 2016 by the authors; licensee MDPI, Basel, Switzerland.

PY - 2016/7/4

Y1 - 2016/7/4

N2 - Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

AB - Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

KW - Autologous serum eye-drops

KW - Dry eye

KW - Spiral microchannel

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Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment

Abstract

Keywords

ASJC Scopus subject areas

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