Microfluidic platforms for studies of angiogenesis, cell migration, and cell-cell interactions: Sixth international bio-fluid mechanics symposium and workshop March 28-30, 2008 Pasadena, California

Seok Chung, Ryo Sudo, Vernella Vickerman, Ioannis K. Zervantonakis, Roger D. Kamm

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide enormous flexibility in controlling the critical biochemical and biomechanical factors that influence cell behavior, (ii) allow for the introduction of multiple cell types in a single system, (iii) provide for the establishment of biochemical gradients in two- or three-dimensional geometries, and (iv) allow for high quality, time-lapse imaging. Here, some of the recent developments are reviewed, with a focus on studies from our own laboratory in three separate areas: angiogenesis, cell migration in the context of tumor cell-endothelial interactions, and liver tissue engineering.

Original languageEnglish
Pages (from-to)1164-1177
Number of pages14
JournalAnnals of Biomedical Engineering
Volume38
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

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Keywords

  • Cancer
  • Cell culture
  • Liver
  • Tissue engineering
  • Vascular networks

ASJC Scopus subject areas

  • Biomedical Engineering

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