Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

Yutaka Nakamura, Hitomi Mimuro, Jun Kunisawa, Yukihiro Furusawa, Daisuke Takahashi, Yumiko Fujimura, Tsuneyasu Kaisho, Hiroshi Kiyono, Koji Hase

Research output: Contribution to journalArticle

Abstract

Infectious colitis is one of the most common health issues worldwide. Microfold (M) cells actively transport luminal antigens to gut-associated lymphoid tissue to induce IgA responses; however, it remains unknown whether M cells contribute to the induction of cellular immune responses. Here we report that M cell-dependent antigen transport plays a critical role in the induction of Th1, Th17, and Th22 responses against gut commensals in the steady state. The establishment of commensal-specific cellular immunity was a prerequisite for preventing bacterial dissemination during enteropathogenic Citrobacter rodentium infection. Therefore, M cell-null mice developed severe colitis with increased bacterial dissemination. This abnormality was associated with mucosal barrier dysfunction. These observations suggest that antigen transport by M cells may help maintain gut immune homeostasis by eliciting antigen-specific cellular immune responses.

Original languageEnglish
JournalMucosal Immunology
DOIs
Publication statusAccepted/In press - 2020 Jan 1

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Nakamura, Y., Mimuro, H., Kunisawa, J., Furusawa, Y., Takahashi, D., Fujimura, Y., Kaisho, T., Kiyono, H., & Hase, K. (Accepted/In press). Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity. Mucosal Immunology. https://doi.org/10.1038/s41385-020-0263-0