@article{a4f2942f1a1d46ccb104148fd70c4d52,
title = "Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity",
abstract = "Infectious colitis is one of the most common health issues worldwide. Microfold (M) cells actively transport luminal antigens to gut-associated lymphoid tissue to induce IgA responses; however, it remains unknown whether M cells contribute to the induction of cellular immune responses. Here we report that M cell-dependent antigen transport plays a critical role in the induction of Th1, Th17, and Th22 responses against gut commensals in the steady state. The establishment of commensal-specific cellular immunity was a prerequisite for preventing bacterial dissemination during enteropathogenic Citrobacter rodentium infection. Therefore, M cell-null mice developed severe colitis with increased bacterial dissemination. This abnormality was associated with mucosal barrier dysfunction. These observations suggest that antigen transport by M cells may help maintain gut immune homeostasis by eliciting antigen-specific cellular immune responses.",
author = "Yutaka Nakamura and Hitomi Mimuro and Jun Kunisawa and Yukihiro Furusawa and Daisuke Takahashi and Yumiko Fujimura and Tsuneyasu Kaisho and Hiroshi Kiyono and Koji Hase",
note = "Funding Information: We would like to thank Yuuki Obata, Chiaki Yarimizu, Shun Murayama, Yu Miyamoto, Takahiro Yamada (Keio University), and Naoki Takemura (IMSUT, Chiba University) for providing technical support. We also thank Yun-Gi Kim (Keio University) for valuable discussions. This study was supported by funding from MEXT and JSPS Grants-in-Aid for Scientific Research (grants 17H04089, 16H01369, 25293114, and 26116709 [to K.H.]; grant 16J05903 [to Y.N.]; grant 17K19551 [to H.M.]; grant 18H02674 [to J.K.]; and grant 18H05280 [to H.K.]), the Japan Agency for Medical Research and Development (AMED) (grants 16gm1010004h0101, 17gm1010004h0102, and 18gm1010004h0103 [to K.H.] and grants 18gm1010006h0002, 18ak0101068h0002, and 18ek0410032s0103 [to J.K.]), The Takeda Science Foundation (to K.H.), The Daiichi Sankyo Foundation of Life Science (to K.H.), The Terumo Foundation for Life Science and Arts (to K.H. and J.K.), The Canon Foundation (to J.K.), The Asahi Glass Foundation (to K.H.), The Naito Foundation (to H.M.), the Grant for Joint Research Project of the Institute of Medical Science, the University of Tokyo (to K.H.), and The Keio University Special Grant-in-Aid for Innovative Collaborative Research Projects (to K.H.). Publisher Copyright: {\textcopyright} 2020, Society for Mucosal Immunology.",
year = "2020",
month = jul,
day = "1",
doi = "10.1038/s41385-020-0263-0",
language = "English",
volume = "13",
pages = "679--690",
journal = "Mucosal Immunology",
issn = "1933-0219",
publisher = "Nature Publishing Group",
number = "4",
}