Micrometer-sized network structure of novel DNA-lipid conjugates induced by heat stimulation

K. Takahashi, M. Matsuo, Taisuke Banno, T. Toyota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have developed a novel lipid-bearing DNA that forms hairpin modules, including a single RNA monomer; this can be used to create micrometer-sized structures from nanometer-sized building blocks during breakage at the RNA site. In the presence of divalent metal ions and heat stimulation, we observed transition of the self-assembly, which results in the formation of a three-dimensional network structure. To our knowledge, this is also the first report of heat-induced micrometer-sized molecular self-assembly of molecules that carry biological information.

Original languageEnglish
Pages (from-to)7053-7058
Number of pages6
JournalSoft Matter
Volume11
Issue number35
DOIs
Publication statusPublished - 2015 Jul 25
Externally publishedYes

Fingerprint

stimulation
Self assembly
lipids
self assembly
micrometers
Bearings (structural)
deoxyribonucleic acid
RNA
Lipids
heat
DNA
Metal ions
metal ions
monomers
modules
Monomers
Molecules
molecules
Hot Temperature

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Micrometer-sized network structure of novel DNA-lipid conjugates induced by heat stimulation. / Takahashi, K.; Matsuo, M.; Banno, Taisuke; Toyota, T.

In: Soft Matter, Vol. 11, No. 35, 25.07.2015, p. 7053-7058.

Research output: Contribution to journalArticle

Takahashi, K. ; Matsuo, M. ; Banno, Taisuke ; Toyota, T. / Micrometer-sized network structure of novel DNA-lipid conjugates induced by heat stimulation. In: Soft Matter. 2015 ; Vol. 11, No. 35. pp. 7053-7058.
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