MicroRNA and endometrial cancer

Roles of small RNAs in human tumors and clinical applications (Review)

Megumi Yanokura, Kouji Banno, Yusuke Kobayashi, Iori Kisu, Arisa Ueki, Asuka Ono, Kennta Masuda, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a relationship between human diseases and the breakdown of gene silencing mechanisms induced by miRNA abnormalities. In particular, abnormal miRNA expression has been detected in various types of cancer and the target genes have been identified. These results indicate that miRNAs act in a manner equivalent to oncogenes or tumor suppressors. miRNAs may also serve as diagnostic biomarkers and therapeutic targets. In this review, we introduce the latest findings on miRNAs in human endometrial cancer, a common malignancy, and discuss the potential of miRNAs as biomarkers and targets for molecular therapy.

Original languageEnglish
Pages (from-to)935-940
Number of pages6
JournalOncology Letters
Volume1
Issue number6
DOIs
Publication statusPublished - 2010 Nov

Fingerprint

Endometrial Neoplasms
MicroRNAs
RNA
Neoplasms
Biomarkers
Small Untranslated RNA
Gene Targeting
Neoplasm Genes
Gene Expression Regulation
Gene Silencing
Oncogenes
Base Pairing
Messenger RNA
Therapeutics

Keywords

  • Biomarker
  • Endometrial cancer
  • MicroRNA
  • Therapeutic drugs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

MicroRNA and endometrial cancer : Roles of small RNAs in human tumors and clinical applications (Review). / Yanokura, Megumi; Banno, Kouji; Kobayashi, Yusuke; Kisu, Iori; Ueki, Arisa; Ono, Asuka; Masuda, Kennta; Nomura, Hiroyuki; Hirasawa, Akira; Susumu, Nobuyuki; Aoki, Daisuke.

In: Oncology Letters, Vol. 1, No. 6, 11.2010, p. 935-940.

Research output: Contribution to journalArticle

Yanokura, Megumi ; Banno, Kouji ; Kobayashi, Yusuke ; Kisu, Iori ; Ueki, Arisa ; Ono, Asuka ; Masuda, Kennta ; Nomura, Hiroyuki ; Hirasawa, Akira ; Susumu, Nobuyuki ; Aoki, Daisuke. / MicroRNA and endometrial cancer : Roles of small RNAs in human tumors and clinical applications (Review). In: Oncology Letters. 2010 ; Vol. 1, No. 6. pp. 935-940.
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AU - Ono, Asuka

AU - Masuda, Kennta

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