MicroRNAs in cancers and neurodegenerative disorders

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs which function as endogenous silencers of various target genes. miRNAs are expressed in a tissue-specific manner and playing important roles in cell proliferation, apoptosis, and differentiation during mammalian development. Links between miRNAs and the initiation and progression of human diseases including cancer are becoming increasingly apparent. Recent studies have revealed that some miRNAs such as miR-9, miR-29 family, and miR-34 family are differentially expressed in Alzheimer's disease, Parkinson's disease, and Huntington's disease. These miRNAs are also reported to act as tumor suppressors during human carcinogenesis. In this review, we discuss about miRNAs which are important in the molecular pathogenesis of both cancer and neurodegeneration. Cancer and neurodegenerative disorder may be influenced by common miRNA pathways that regulate differentiation, proliferation, and death of cells.

Original languageEnglish
Article numberArticle 194
JournalFrontiers in Genetics
Volume3
Issue numberSEP
DOIs
Publication statusPublished - 2012 Dec 1

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Keywords

  • Cancer
  • MiR-29a/29b-1
  • MiR-34b/34c
  • MiR-9
  • MicroRNA
  • Neurodegenerative disorder

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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