MicroRNAs in endometrial cancer

Kouji Banno, Megumi Yanokura, Iori Kisu, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) of approximately 22 bp that induce RNA interference with a complementary messenger RNA (mRNA) and act in silencing of mRNA. miRNAs are strongly associated with cancer development and those involved in carcinogenesis are classified into oncogenic miRNAs and tumor suppressor miRNAs (tumor suppressor miRs). Specific miRNAs are expressed in various tissues and changes in regulation of gene expression are thought to cause carcinogenesis. Thus, tissue-specific miRNAs may be biomarkers for cancer diagnosis and prognosis. Approaches to application of miRNAs as cancer therapy are also ongoing, based on the involvement of miRNAs in carcinogenesis. In endometrial cancer, miRNAs are associated with regulation of gene expression, epigenetic dysfunction and carcinogenesis. Thus, miRNAs are likely to have key roles in diagnosis, prognostic prediction, and therapy in endometrial cancer.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalInternational Journal of Clinical Oncology
Volume18
Issue number2
DOIs
Publication statusPublished - 2013 Apr

Keywords

  • Endometrial cancer
  • Epigenetic
  • MicroRNA
  • miR-152
  • miR-34b

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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