MicroRNAs in hepatobiliary and pancreatic cancers

Yoshimasa Saito, Hidekazu Suzuki, Misa Matsuura, Ayami Sato, Yusuke Kasai, Kana Yamada, Hidetsugu Saito, Toshifumi Hibi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of numerous target genes. Hundreds of miRNAs have been identified in the human genome. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Aberrant expression of miRNAs may also contribute to the development and progression of human hepatobiliary and pancreatic cancers. Recent studies have shown that some miRNAs play roles as tumor suppressors or oncogenes in hepatobiliary and pancreatic cancers. miR-122, let-7 family, and miR-101 are down-regulated in hepatocellular carcinoma (HCC), suggesting that it is a potential tumor suppressor of HCC. miR-221 and miR-222 are up-regulated in HCC and may act as oncogenic miRNAs in hepatocarcinogenesis. miRNA expression profiling may be a powerful clinical tool for diagnosis and regulation of miRNA expression could be a novel therapeutic strategy for hepatobiliary and pancreatic cancers. In this review, we summarize current knowledge about the roles of important tumor suppressor microRNAs and oncogenic microRNAs in hepatobiliary and pancreatic cancers.

Original languageEnglish
Article numberArticle 66
JournalFrontiers in Genetics
Volume2
Issue numberSEP
DOIs
Publication statusPublished - 2011

Fingerprint

MicroRNAs
Pancreatic Neoplasms
Hepatocellular Carcinoma
Small Untranslated RNA
Neoplasms
Human Development
Human Genome
Oncogenes
Cell Differentiation
Cell Proliferation
Apoptosis

Keywords

  • Cholangiocarcinoma
  • Epigenetics
  • Hepatocellular carcinoma
  • MicroRNA
  • Oncogene
  • Pancreatic cancer
  • Tumor suppressor

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Genetics(clinical)

Cite this

Saito, Y., Suzuki, H., Matsuura, M., Sato, A., Kasai, Y., Yamada, K., ... Hibi, T. (2011). MicroRNAs in hepatobiliary and pancreatic cancers. Frontiers in Genetics, 2(SEP), [Article 66]. https://doi.org/10.3389/fgene.2011.00066

MicroRNAs in hepatobiliary and pancreatic cancers. / Saito, Yoshimasa; Suzuki, Hidekazu; Matsuura, Misa; Sato, Ayami; Kasai, Yusuke; Yamada, Kana; Saito, Hidetsugu; Hibi, Toshifumi.

In: Frontiers in Genetics, Vol. 2, No. SEP, Article 66, 2011.

Research output: Contribution to journalArticle

Saito, Y, Suzuki, H, Matsuura, M, Sato, A, Kasai, Y, Yamada, K, Saito, H & Hibi, T 2011, 'MicroRNAs in hepatobiliary and pancreatic cancers', Frontiers in Genetics, vol. 2, no. SEP, Article 66. https://doi.org/10.3389/fgene.2011.00066
Saito Y, Suzuki H, Matsuura M, Sato A, Kasai Y, Yamada K et al. MicroRNAs in hepatobiliary and pancreatic cancers. Frontiers in Genetics. 2011;2(SEP). Article 66. https://doi.org/10.3389/fgene.2011.00066
Saito, Yoshimasa ; Suzuki, Hidekazu ; Matsuura, Misa ; Sato, Ayami ; Kasai, Yusuke ; Yamada, Kana ; Saito, Hidetsugu ; Hibi, Toshifumi. / MicroRNAs in hepatobiliary and pancreatic cancers. In: Frontiers in Genetics. 2011 ; Vol. 2, No. SEP.
@article{e19733ed0dbc4766a23be8628f648874,
title = "MicroRNAs in hepatobiliary and pancreatic cancers",
abstract = "MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of numerous target genes. Hundreds of miRNAs have been identified in the human genome. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Aberrant expression of miRNAs may also contribute to the development and progression of human hepatobiliary and pancreatic cancers. Recent studies have shown that some miRNAs play roles as tumor suppressors or oncogenes in hepatobiliary and pancreatic cancers. miR-122, let-7 family, and miR-101 are down-regulated in hepatocellular carcinoma (HCC), suggesting that it is a potential tumor suppressor of HCC. miR-221 and miR-222 are up-regulated in HCC and may act as oncogenic miRNAs in hepatocarcinogenesis. miRNA expression profiling may be a powerful clinical tool for diagnosis and regulation of miRNA expression could be a novel therapeutic strategy for hepatobiliary and pancreatic cancers. In this review, we summarize current knowledge about the roles of important tumor suppressor microRNAs and oncogenic microRNAs in hepatobiliary and pancreatic cancers.",
keywords = "Cholangiocarcinoma, Epigenetics, Hepatocellular carcinoma, MicroRNA, Oncogene, Pancreatic cancer, Tumor suppressor",
author = "Yoshimasa Saito and Hidekazu Suzuki and Misa Matsuura and Ayami Sato and Yusuke Kasai and Kana Yamada and Hidetsugu Saito and Toshifumi Hibi",
year = "2011",
doi = "10.3389/fgene.2011.00066",
language = "English",
volume = "2",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S. A.",
number = "SEP",

}

TY - JOUR

T1 - MicroRNAs in hepatobiliary and pancreatic cancers

AU - Saito, Yoshimasa

AU - Suzuki, Hidekazu

AU - Matsuura, Misa

AU - Sato, Ayami

AU - Kasai, Yusuke

AU - Yamada, Kana

AU - Saito, Hidetsugu

AU - Hibi, Toshifumi

PY - 2011

Y1 - 2011

N2 - MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of numerous target genes. Hundreds of miRNAs have been identified in the human genome. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Aberrant expression of miRNAs may also contribute to the development and progression of human hepatobiliary and pancreatic cancers. Recent studies have shown that some miRNAs play roles as tumor suppressors or oncogenes in hepatobiliary and pancreatic cancers. miR-122, let-7 family, and miR-101 are down-regulated in hepatocellular carcinoma (HCC), suggesting that it is a potential tumor suppressor of HCC. miR-221 and miR-222 are up-regulated in HCC and may act as oncogenic miRNAs in hepatocarcinogenesis. miRNA expression profiling may be a powerful clinical tool for diagnosis and regulation of miRNA expression could be a novel therapeutic strategy for hepatobiliary and pancreatic cancers. In this review, we summarize current knowledge about the roles of important tumor suppressor microRNAs and oncogenic microRNAs in hepatobiliary and pancreatic cancers.

AB - MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of numerous target genes. Hundreds of miRNAs have been identified in the human genome. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Aberrant expression of miRNAs may also contribute to the development and progression of human hepatobiliary and pancreatic cancers. Recent studies have shown that some miRNAs play roles as tumor suppressors or oncogenes in hepatobiliary and pancreatic cancers. miR-122, let-7 family, and miR-101 are down-regulated in hepatocellular carcinoma (HCC), suggesting that it is a potential tumor suppressor of HCC. miR-221 and miR-222 are up-regulated in HCC and may act as oncogenic miRNAs in hepatocarcinogenesis. miRNA expression profiling may be a powerful clinical tool for diagnosis and regulation of miRNA expression could be a novel therapeutic strategy for hepatobiliary and pancreatic cancers. In this review, we summarize current knowledge about the roles of important tumor suppressor microRNAs and oncogenic microRNAs in hepatobiliary and pancreatic cancers.

KW - Cholangiocarcinoma

KW - Epigenetics

KW - Hepatocellular carcinoma

KW - MicroRNA

KW - Oncogene

KW - Pancreatic cancer

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=84864761176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864761176&partnerID=8YFLogxK

U2 - 10.3389/fgene.2011.00066

DO - 10.3389/fgene.2011.00066

M3 - Article

C2 - 22303361

AN - SCOPUS:84864761176

VL - 2

JO - Frontiers in Genetics

JF - Frontiers in Genetics

SN - 1664-8021

IS - SEP

M1 - Article 66

ER -