Microscale organization of chondrocyte array in hydrogel by dielectrophoresis

S. Miyata, Y. Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recently, microfabrication tools have been utilized to quantify the role of the cellular microenvironment on cell activity and function. Improving tissue regeneration by cell culture on scaffold material will also require tools to control cellular organization in 3-dimentional (3-D) condition. Our objective was to improve cartilage tissue engineering using 3-D cell organization technology. In this study, we developed an anisotropic cartilaginous tissue by cell patterning within hydrogel slabs using dielectrophoretic (DEP) forces. Our data indicate that the embedded chondrocytes remained viable and reconstructed cartilaginous tissue along the patterned cell array. DEP cell patterning may become a useful approach for reconstructing anisotropic structure in cartilage regeneration.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationMicro- and Nanosystems in Medicine, Active Implants, Biosensors
Pages233-234
Number of pages2
Edition8
DOIs
Publication statusPublished - 2009 Dec 1
EventWorld Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors - Munich, Germany
Duration: 2009 Sep 72009 Sep 12

Publication series

NameIFMBE Proceedings
Number8
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors
CountryGermany
CityMunich
Period09/9/709/9/12

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Keywords

  • Cartilage
  • Chondrocyte
  • Dielectrophoresis
  • MEMS
  • Tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Miyata, S., & Takeuchi, Y. (2009). Microscale organization of chondrocyte array in hydrogel by dielectrophoresis. In World Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors (8 ed., pp. 233-234). (IFMBE Proceedings; Vol. 25, No. 8). https://doi.org/10.1007/978-3-642-03887-7-65