Microvascular oxidative stress, immune reaction and apoptosis in hypertensives

Hidekazu Suzuki, Makoto Suematsu, Geert W. Schmid-Schönbein

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The mechanisms that lead to organ injury in hypertension are incompletely understood. In particular, there is a lack of evidence that serves to link the elevation of arterial blood pressure with end organ damage. Experimental models of hypertension have a range of microvascular abnormalities in addition to a shift in blood pressure. There is evidence for an oxidative stress in microvascular endothelium derived from xanthine and NADPH oxidase. Furthermore, there exists an immune suppression accompanied by abnormally elevated circulating leukocyte counts, depression of selectin membrane adhesion to the endothelium and enhanced cell apoptosis. Many of the deficiencies in the spontaneously hypertensive rats can be corrected by adrenalectomy, suggesting a contribution of glucocorticoids to the abnormalities in this model. These observations suggest a significantly enhanced vascular oxidative stress which is accompanied by a frustrated inflammatory response due to a glucocorticoid dependent deficiency of leukocyte adhesion to vascular endothelium.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalClinical Hemorheology and Microcirculation
Volume21
Issue number3-4
Publication statusPublished - 1999

Fingerprint

Glucocorticoids
Endothelium
Oxidative Stress
Apoptosis
Hypertension
Selectins
Xanthine Oxidase
NADPH Oxidase
Adrenalectomy
Vascular Endothelium
Inbred SHR Rats
Leukocyte Count
Blood Vessels
Arterial Pressure
Leukocytes
Theoretical Models
Blood Pressure
Membranes
Wounds and Injuries

ASJC Scopus subject areas

  • Hematology
  • Physiology

Cite this

Suzuki, H., Suematsu, M., & Schmid-Schönbein, G. W. (1999). Microvascular oxidative stress, immune reaction and apoptosis in hypertensives. Clinical Hemorheology and Microcirculation, 21(3-4), 161-168.

Microvascular oxidative stress, immune reaction and apoptosis in hypertensives. / Suzuki, Hidekazu; Suematsu, Makoto; Schmid-Schönbein, Geert W.

In: Clinical Hemorheology and Microcirculation, Vol. 21, No. 3-4, 1999, p. 161-168.

Research output: Contribution to journalArticle

Suzuki, H, Suematsu, M & Schmid-Schönbein, GW 1999, 'Microvascular oxidative stress, immune reaction and apoptosis in hypertensives', Clinical Hemorheology and Microcirculation, vol. 21, no. 3-4, pp. 161-168.
Suzuki, Hidekazu ; Suematsu, Makoto ; Schmid-Schönbein, Geert W. / Microvascular oxidative stress, immune reaction and apoptosis in hypertensives. In: Clinical Hemorheology and Microcirculation. 1999 ; Vol. 21, No. 3-4. pp. 161-168.
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