Midkine gene transfer in brain infarction

Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita, Yasuhiro Kumai

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cerebrovascular disease is the leading cause of death and disability in Japan and most Western countries. Gene transfer techniques may be applicable to the treatment of serious types of stroke, since several experimental studies have revealed the usefulness of gene therapy in the prevention of vasospasm after subarachnoid hemorrhage, reduction of infarct size and improvement of neuronal functions. Midkine is reported to have anti-apoptotic effects, and the gene transfer of midkine to the ischemic brain may provide neuroprotective effects. Furthermore, chemotactic effects of midkine could be utilized for the neurogenesis and functional recovery. We describe the novel possibility of the stroke treatment using midkine gene transfer.

Original languageEnglish
Title of host publicationMidkine
Subtitle of host publicationFrom Embryogenesis to Pathogenesis and Therapy
PublisherSpringer Netherlands
Pages153-163
Number of pages11
ISBN (Electronic)9789400742345
ISBN (Print)9400742339, 9789400742338
DOIs
Publication statusPublished - 2012 Nov 1

Keywords

  • Brain
  • Gene therapy
  • Ischemia
  • Midkine
  • Neurogenesis
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Ooboshi, H., Ishikawa, E., Takada, J., Shichita, T., & Kumai, Y. (2012). Midkine gene transfer in brain infarction. In Midkine: From Embryogenesis to Pathogenesis and Therapy (pp. 153-163). Springer Netherlands. https://doi.org/10.1007/978-94-007-4234-5_13