Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.

Yuhei Arai, Hironobu Iinuma, Yoko Ikeda, Masayuki Igarashi, Masaki Hatano, Naoko Kinoshita, Tamami Ukaji, Siro Simizu, Kazuo Umezawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC 50 values of 1.31 and 1.99 μg ml -1, respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalJournal of Antibiotics
Volume66
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

Keywords

  • Breast carcinoma
  • Cancer cell migration
  • Luminacin
  • Migracin
  • Streptomyces sp.

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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  • Cite this

    Arai, Y., Iinuma, H., Ikeda, Y., Igarashi, M., Hatano, M., Kinoshita, N., Ukaji, T., Simizu, S., & Umezawa, K. (2013). Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp. Journal of Antibiotics, 66(4), 225-230. https://doi.org/10.1038/ja.2012.112