Migraine-update - Current concepts of migraine pathogenesis

Norihiro Suzuki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The pathophysiology of migraine still remains unclear. However, abundant evidence in support of the view that migraine as an illness of the central nervous system has been accumulated. First, the hyperexitability in the brain is recognized even in the stage between attacks in migraineurs according to findings of transcranial magnetic stimulation techniques, MRI-BOLD studies or 31P SPECT examinations. Second, cortical spreading depression originating in the occipital cortex is more likely to be related to the aura. Third, sensitization of the trigeminal nerve system is substantially involved in process of headache pain in migraine. Fourth, clonic dysfunction of the priaqueductal gray matter in the brain stem may underlie the migraine pathogenesis. Thus, current concept of susceptibility of migraine is attributed to certain dysfunction of the deep brain structures such as the brain stem rather than the blood vessels in the brain or dura mater.

Original languageEnglish
Pages (from-to)834-836
Number of pages3
JournalClinical Neurology
Volume45
Issue number11
Publication statusPublished - 2005 Nov

Fingerprint

Migraine Disorders
Brain Stem
Brain
Cortical Spreading Depression
Dura Mater
Occipital Lobe
Trigeminal Nerve
Transcranial Magnetic Stimulation
Single-Photon Emission-Computed Tomography
Blood Vessels
Headache
Epilepsy
Central Nervous System
Pain

Keywords

  • Allodynia
  • Aura
  • Cortical spreading depression
  • Migraine
  • Sensitization

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Migraine-update - Current concepts of migraine pathogenesis. / Suzuki, Norihiro.

In: Clinical Neurology, Vol. 45, No. 11, 11.2005, p. 834-836.

Research output: Contribution to journalArticle

Suzuki, Norihiro. / Migraine-update - Current concepts of migraine pathogenesis. In: Clinical Neurology. 2005 ; Vol. 45, No. 11. pp. 834-836.
@article{f56f8de75942407d8295d01cbedaa23c,
title = "Migraine-update - Current concepts of migraine pathogenesis",
abstract = "The pathophysiology of migraine still remains unclear. However, abundant evidence in support of the view that migraine as an illness of the central nervous system has been accumulated. First, the hyperexitability in the brain is recognized even in the stage between attacks in migraineurs according to findings of transcranial magnetic stimulation techniques, MRI-BOLD studies or 31P SPECT examinations. Second, cortical spreading depression originating in the occipital cortex is more likely to be related to the aura. Third, sensitization of the trigeminal nerve system is substantially involved in process of headache pain in migraine. Fourth, clonic dysfunction of the priaqueductal gray matter in the brain stem may underlie the migraine pathogenesis. Thus, current concept of susceptibility of migraine is attributed to certain dysfunction of the deep brain structures such as the brain stem rather than the blood vessels in the brain or dura mater.",
keywords = "Allodynia, Aura, Cortical spreading depression, Migraine, Sensitization",
author = "Norihiro Suzuki",
year = "2005",
month = "11",
language = "English",
volume = "45",
pages = "834--836",
journal = "Clinical Neurology",
issn = "0009-918X",
publisher = "Societas Neurologica Japonica",
number = "11",

}

TY - JOUR

T1 - Migraine-update - Current concepts of migraine pathogenesis

AU - Suzuki, Norihiro

PY - 2005/11

Y1 - 2005/11

N2 - The pathophysiology of migraine still remains unclear. However, abundant evidence in support of the view that migraine as an illness of the central nervous system has been accumulated. First, the hyperexitability in the brain is recognized even in the stage between attacks in migraineurs according to findings of transcranial magnetic stimulation techniques, MRI-BOLD studies or 31P SPECT examinations. Second, cortical spreading depression originating in the occipital cortex is more likely to be related to the aura. Third, sensitization of the trigeminal nerve system is substantially involved in process of headache pain in migraine. Fourth, clonic dysfunction of the priaqueductal gray matter in the brain stem may underlie the migraine pathogenesis. Thus, current concept of susceptibility of migraine is attributed to certain dysfunction of the deep brain structures such as the brain stem rather than the blood vessels in the brain or dura mater.

AB - The pathophysiology of migraine still remains unclear. However, abundant evidence in support of the view that migraine as an illness of the central nervous system has been accumulated. First, the hyperexitability in the brain is recognized even in the stage between attacks in migraineurs according to findings of transcranial magnetic stimulation techniques, MRI-BOLD studies or 31P SPECT examinations. Second, cortical spreading depression originating in the occipital cortex is more likely to be related to the aura. Third, sensitization of the trigeminal nerve system is substantially involved in process of headache pain in migraine. Fourth, clonic dysfunction of the priaqueductal gray matter in the brain stem may underlie the migraine pathogenesis. Thus, current concept of susceptibility of migraine is attributed to certain dysfunction of the deep brain structures such as the brain stem rather than the blood vessels in the brain or dura mater.

KW - Allodynia

KW - Aura

KW - Cortical spreading depression

KW - Migraine

KW - Sensitization

UR - http://www.scopus.com/inward/record.url?scp=31544436031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31544436031&partnerID=8YFLogxK

M3 - Article

VL - 45

SP - 834

EP - 836

JO - Clinical Neurology

JF - Clinical Neurology

SN - 0009-918X

IS - 11

ER -