Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1 taxonomy, fermentation, isolation and biological activities

K. Nakae, Y. Yoshimoto, T. Sawa, Y. Homma, M. Hamada, T. Takeuchi, M. Imoto

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Abstract

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.

Original languageEnglish
Pages (from-to)1130-1136
Number of pages7
JournalJournal of Antibiotics
Volume53
Issue number10
DOIs
Publication statusPublished - 2000 Jan 1

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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