Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta

Shimpei Sumimoto, Masayuki Kobayashi, Rio Sato, Seiichi Shinomiya, Arihiro Iwasaki, Shoichiro Suda, Toshiaki Teruya, Toshiyasu Inuzuka, Osamu Ohno, Kiyotake Suenaga

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC 50 value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.

Original languageEnglish
JournalOrganic Letters
DOIs
Publication statusPublished - 2019 Jan 1

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Lipopeptides
Cyanobacteria
Cell death
HeLa Cells
death
Copper
Reactive Oxygen Species
Cell Death
High Pressure Liquid Chromatography
degradation
Degradation
copper
oxygen
Growth
configurations
cells

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta. / Sumimoto, Shimpei; Kobayashi, Masayuki; Sato, Rio; Shinomiya, Seiichi; Iwasaki, Arihiro; Suda, Shoichiro; Teruya, Toshiaki; Inuzuka, Toshiyasu; Ohno, Osamu; Suenaga, Kiyotake.

In: Organic Letters, 01.01.2019.

Research output: Contribution to journalArticle

Sumimoto, Shimpei ; Kobayashi, Masayuki ; Sato, Rio ; Shinomiya, Seiichi ; Iwasaki, Arihiro ; Suda, Shoichiro ; Teruya, Toshiaki ; Inuzuka, Toshiyasu ; Ohno, Osamu ; Suenaga, Kiyotake. / Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta. In: Organic Letters. 2019.
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