Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta

Shimpei Sumimoto, Masayuki Kobayashi, Rio Sato, Seiichi Shinomiya, Arihiro Iwasaki, Shoichiro Suda, Toshiaki Teruya, Toshiyasu Inuzuka, Osamu Ohno, Kiyotake Suenaga

Research output: Contribution to journalArticle

2 Citations (Scopus)


Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC 50 value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.

Original languageEnglish
JournalOrganic Letters
Publication statusPublished - 2019 Jan 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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