Minute pulmonary meningothelial-like nodules: clinicopathologic analysis of 121 patients

Eiki Mizutani, Koji Tsuta, Akiko M. Maeshima, Hisao Asamura, Yoshihiro Matsuno

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Minute pulmonary meningothelial-like nodules (MPMNs) are generally detected incidentally in resected lung specimens. With the development of diagnostic radiology, MPMNs have occasionally been detected on thin-section computed tomography. Their clinicopathologic background remains unclear because there have been no reports of a large series of patients with them. Among 1724 pulmonary resections during a 4 1/2 year period, 271 MPMNs were identified in 121 patients (7.0%) after pathologic examination. Minute pulmonary meningothelial-like nodules were seen more often in females than in males (10.7% versus 4.5%; odds ratio, 2.01; 95% confidence interval, 1.36-2.97; P < .001). Minute pulmonary meningothelial-like nodules were present in all lobes, and the frequency of incidence was not different between lobes. The incidence frequency of MPMNs was not different between age groups. Minute pulmonary meningothelial-like nodules were found more often in patients with malignant pulmonary tumors than in those with benign disease (7.3% versus 2.5%; P = .044). In particular, MPMNs were found more often in patients with lung adenocarcinoma than with other primary pulmonary malignant tumors (9.4% versus 4.5%; odds ratio, 2.33; 95% confidence interval, 1.35-4.02; P < .01). There was no significant difference in clinicopathologic factors between patients with single and multiple MPMNs, except for the size of each nodule.

Original languageEnglish
Pages (from-to)678-682
Number of pages5
JournalHuman Pathology
Volume40
Issue number5
DOIs
Publication statusPublished - 2009 May
Externally publishedYes

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Lung
Odds Ratio
Confidence Intervals
Incidence
Radiology
Neoplasms
Age Groups
Tomography

Keywords

  • Lung
  • Meningothelial-like nodule
  • Meningothelioid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Minute pulmonary meningothelial-like nodules : clinicopathologic analysis of 121 patients. / Mizutani, Eiki; Tsuta, Koji; Maeshima, Akiko M.; Asamura, Hisao; Matsuno, Yoshihiro.

In: Human Pathology, Vol. 40, No. 5, 05.2009, p. 678-682.

Research output: Contribution to journalArticle

Mizutani, Eiki ; Tsuta, Koji ; Maeshima, Akiko M. ; Asamura, Hisao ; Matsuno, Yoshihiro. / Minute pulmonary meningothelial-like nodules : clinicopathologic analysis of 121 patients. In: Human Pathology. 2009 ; Vol. 40, No. 5. pp. 678-682.
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