Abstract
Ovulation in the mouse and other mammals is controlled by hormones secreted by the hypothalamo-pituitary-ovarian axis. We describe anovulation and infertility in female mice lacking the microRNAs miR-200b and miR-429. Both miRNAs are strongly expressed in the pituitary gland, where they suppress expression of the transcriptional repressor ZEB1. Eliminating these miRNAs, in turn, inhibits luteinizing hormone (LH) synthesis by repressing transcription of its β-subunit gene, which leads to lowered serum LH concentration, an impaired LH surge, and failure to ovulate. Our results reveal roles for miR-200b and miR-429, and their target the Zeb1 gene, in the regulation of mammalian reproduction. Thus, the hypothalamo-pituitary-ovarian axis was shown to require miR-200b and miR-429 to support ovulation.
| Original language | English |
|---|---|
| Pages (from-to) | 71-73 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 341 |
| Issue number | 6141 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Cite this
MiR-200b and miR-429 function in mouse ovulation and are essential for female fertility. / Hasuwa, Hidetoshi; Ueda, Jun; Ikawa, Masahito; Okabe, Masaru.
In: Science, Vol. 341, No. 6141, 2013, p. 71-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MiR-200b and miR-429 function in mouse ovulation and are essential for female fertility
AU - Hasuwa, Hidetoshi
AU - Ueda, Jun
AU - Ikawa, Masahito
AU - Okabe, Masaru
PY - 2013
Y1 - 2013
N2 - Ovulation in the mouse and other mammals is controlled by hormones secreted by the hypothalamo-pituitary-ovarian axis. We describe anovulation and infertility in female mice lacking the microRNAs miR-200b and miR-429. Both miRNAs are strongly expressed in the pituitary gland, where they suppress expression of the transcriptional repressor ZEB1. Eliminating these miRNAs, in turn, inhibits luteinizing hormone (LH) synthesis by repressing transcription of its β-subunit gene, which leads to lowered serum LH concentration, an impaired LH surge, and failure to ovulate. Our results reveal roles for miR-200b and miR-429, and their target the Zeb1 gene, in the regulation of mammalian reproduction. Thus, the hypothalamo-pituitary-ovarian axis was shown to require miR-200b and miR-429 to support ovulation.
AB - Ovulation in the mouse and other mammals is controlled by hormones secreted by the hypothalamo-pituitary-ovarian axis. We describe anovulation and infertility in female mice lacking the microRNAs miR-200b and miR-429. Both miRNAs are strongly expressed in the pituitary gland, where they suppress expression of the transcriptional repressor ZEB1. Eliminating these miRNAs, in turn, inhibits luteinizing hormone (LH) synthesis by repressing transcription of its β-subunit gene, which leads to lowered serum LH concentration, an impaired LH surge, and failure to ovulate. Our results reveal roles for miR-200b and miR-429, and their target the Zeb1 gene, in the regulation of mammalian reproduction. Thus, the hypothalamo-pituitary-ovarian axis was shown to require miR-200b and miR-429 to support ovulation.
UR - http://www.scopus.com/inward/record.url?scp=84879796694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879796694&partnerID=8YFLogxK
U2 - 10.1126/science.1237999
DO - 10.1126/science.1237999
M3 - Article
C2 - 23765281
AN - SCOPUS:84879796694
VL - 341
SP - 71
EP - 73
JO - Science
JF - Science
SN - 0036-8075
IS - 6141
ER -