Misprocessed tRNA response targets piRNA clusters

Soichiro Yamanaka, Haruhiko Siomi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Germline PIWI-interacting RNA (piRNA) clusters have a characteristic transcriptional status; although they do not have their own promoters, both genomic strands are transcribed, while splicing and 3' processing signals are neglected. How this transcription is maintained remains unknown. Molla-Herman et al (2015) discovered that mutations in a tRNA processing factor cause the loss of transcription at some piRNA clusters, leading to sterility in Drosophila melanogaster. This defect in piRNA cluster transcription is restored by mutations in genes required for the DNA damage checkpoint or replication.

Original languageEnglish
Pages (from-to)2988-2989
Number of pages2
JournalEMBO Journal
Volume34
Issue number24
DOIs
Publication statusPublished - 2015 Dec 14

Fingerprint

Transcription
Transfer RNA
RNA
Mutation
Drosophila melanogaster
DNA Replication
Infertility
DNA Damage
Signal processing
Genes
Defects
DNA
Processing

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Misprocessed tRNA response targets piRNA clusters. / Yamanaka, Soichiro; Siomi, Haruhiko.

In: EMBO Journal, Vol. 34, No. 24, 14.12.2015, p. 2988-2989.

Research output: Contribution to journalArticle

Yamanaka, Soichiro ; Siomi, Haruhiko. / Misprocessed tRNA response targets piRNA clusters. In: EMBO Journal. 2015 ; Vol. 34, No. 24. pp. 2988-2989.
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