Missense mutations of the BRAF gene in human lung adenocarcinoma

Katsuhiko Naoki, Tzu Hsiu Chen, William G. Richards, David J. Sugarbaker, Matthew Meyerson

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Mutations of the BRAF protein serine/threonine kinase gene have recently been identified in a variety of human cancers, most notably melanomas. We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. Analysis of BRAF sequence from 127 primary human lung adenocarcinomas revealed mutations in two tumor specimens, one in exon 11 (G465V), and a second in exon 15 (L596R). These specimens belong to the same adenocarcinoma subgroup as defined by clustering of gene expression data. BRAF may provide a target for anticancer chemotherapy in a subset of lung adenocarcinoma patients.

Original languageEnglish
Pages (from-to)7001-7003
Number of pages3
JournalCancer Research
Volume62
Issue number23
Publication statusPublished - 2002 Dec 1
Externally publishedYes

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Missense Mutation
Exons
Proto-Oncogene Proteins B-raf
Genes
Mutation
Protein-Serine-Threonine Kinases
Mutation Rate
Sequence Analysis
Cluster Analysis
Melanoma
Lung Neoplasms
Neoplasms
Adenocarcinoma
Gene Expression
Drug Therapy
Adenocarcinoma of lung

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Naoki, K., Chen, T. H., Richards, W. G., Sugarbaker, D. J., & Meyerson, M. (2002). Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Research, 62(23), 7001-7003.

Missense mutations of the BRAF gene in human lung adenocarcinoma. / Naoki, Katsuhiko; Chen, Tzu Hsiu; Richards, William G.; Sugarbaker, David J.; Meyerson, Matthew.

In: Cancer Research, Vol. 62, No. 23, 01.12.2002, p. 7001-7003.

Research output: Contribution to journalArticle

Naoki, K, Chen, TH, Richards, WG, Sugarbaker, DJ & Meyerson, M 2002, 'Missense mutations of the BRAF gene in human lung adenocarcinoma', Cancer Research, vol. 62, no. 23, pp. 7001-7003.
Naoki K, Chen TH, Richards WG, Sugarbaker DJ, Meyerson M. Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Research. 2002 Dec 1;62(23):7001-7003.
Naoki, Katsuhiko ; Chen, Tzu Hsiu ; Richards, William G. ; Sugarbaker, David J. ; Meyerson, Matthew. / Missense mutations of the BRAF gene in human lung adenocarcinoma. In: Cancer Research. 2002 ; Vol. 62, No. 23. pp. 7001-7003.
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