Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'

An A. Kazuno, Kae Munakata, Kanako Mori, Masashi Tanaka, Shinichiro Nanko, Hiroshi Kunugi, Tadashi Umekage, Mamoru Tochigi, Kazuhisa Kohda, Tsukasa Sasaki, Tsuyoshi Akiyama, Shinsuke Washizuka, Nobumasa Kato, Tadafumi Kato

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Although classical psychopathological studies have shown the presence of an independent diagnostic category, 'atypical psychosis', most psychotic patients are currently classified into two major diagnostic categories, schizophrenia and bipolar disorder, by the Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) criteria. 'Atypical psychosis' is characterized by acute confusion without systematic delusion, emotional instability, and psychomotor excitement or stupor. Such clinical features resemble those seen in organic mental syndrome, and differential diagnosis is often difficult. Because patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) sometimes show organic mental disorder, 'atypical psychosis' may be caused by mutations of mitochondrial DNA (mtDNA) in some patients. In the present study whole mtDNA was sequenced for seven patients with various psychotic disorders, who could be categorized as 'atypical psychosis'. None of them had known mtDNA mutations pathogenic for mitochondrial encephalopathy. Two of seven patients belonged to a subhaplogroup F1b1a with low frequency. These results did not support the hypothesis that clinical presentation of some patients with 'atypical psychosis' is a reflection of subclinical mitochondrial encephalopathy. However, the subhaplogroup F1b1a may be a good target for association study of 'atypical psychosis'.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalPsychiatry and Clinical Neurosciences
Volume59
Issue number4
DOIs
Publication statusPublished - 2005 Aug

Keywords

  • 'Atypical psychosis'
  • Association study
  • Genetics
  • Mitochondrial DNA
  • Mitochondrial myopathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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