Mitochondrial genome variation in Eastern Asia and the peopling of Japan

Masashi Tanaka, Vicente M. Cabrera, Ana M. González, José M. Larruga, Takeshi Takeyasu, Noriyuki Fuku, Li Jun Guo, Raita Hirose, Yasunori Fujita, Miyuki Kurata, Ken Ichi Shinoda, Kazuo Umetsu, Yoshiji Yamada, Yoshiharu Oshida, Yuzo Sato, Nobutaka Hattori, Yoshikuni Mizuno, Yasumichi Arai, Nobuyoshi Hirose, Shigeo OhtaOsamu Ogawa, Yasushi Tanaka, Ryuzo Kawamori, Masayo Shamoto-Nagai, Wakako Maruyama, Hiroshi Shimokata, Ryota Suzuki, Hidetoshi Shimodaira

Research output: Contribution to journalArticle

372 Citations (Scopus)

Abstract

To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the complete mitochondrial genomes of 672 Japanese individuals (http://www.giib.or.jp/mtsnp/index_e.html). This allowed us to perform a phylogenetic analysis with a pool of 942 Asiatic sequences. New clades and subclades emerged from the Japanese data. On the basis of this unequivocal phylogeny, we classified 4713 Asian partial mitochondrial sequences, with <10% ambiguity. Applying population and phylogeographic methods, we used these sequences to shed light on the controversial issue of the peopling of Japan. Population-based comparisons confirmed that present-day Japanese have their closest genetic affinity to northern Asian populations, especially to Koreans, which finding is congruent with the proposed Continental gene flow to Japan after the Yayoi period. This phylogeographic approach unraveled a high degree of differentiation in Paleolithic Japanese. Ancient southern and northern migrations were detected based on the existence of basic M and N lineages in Ryukyuans and Ainu. Direct connections with Tibet, parallel to those found for the Y-chromosome, were also apparent. Furthermore, the highest diversity found in Japan for some derived clades suggests that Japan could be included in an area of migratory expansion to Continental Asia. All the theories that have been proposed up to now to explain the peopling of Japan seem insufficient to accommodate fully this complex picture.

Original languageEnglish
Pages (from-to)1832-1850
Number of pages19
JournalGenome Research
Volume14
Issue number10 A
Publication statusPublished - 2004 Oct

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Mitochondrial Genome
Far East
Japan
Phylogeny
Tibet
Population
Gene Flow
Y Chromosome
Mitochondrial DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Tanaka, M., Cabrera, V. M., González, A. M., Larruga, J. M., Takeyasu, T., Fuku, N., ... Shimodaira, H. (2004). Mitochondrial genome variation in Eastern Asia and the peopling of Japan. Genome Research, 14(10 A), 1832-1850.

Mitochondrial genome variation in Eastern Asia and the peopling of Japan. / Tanaka, Masashi; Cabrera, Vicente M.; González, Ana M.; Larruga, José M.; Takeyasu, Takeshi; Fuku, Noriyuki; Guo, Li Jun; Hirose, Raita; Fujita, Yasunori; Kurata, Miyuki; Shinoda, Ken Ichi; Umetsu, Kazuo; Yamada, Yoshiji; Oshida, Yoshiharu; Sato, Yuzo; Hattori, Nobutaka; Mizuno, Yoshikuni; Arai, Yasumichi; Hirose, Nobuyoshi; Ohta, Shigeo; Ogawa, Osamu; Tanaka, Yasushi; Kawamori, Ryuzo; Shamoto-Nagai, Masayo; Maruyama, Wakako; Shimokata, Hiroshi; Suzuki, Ryota; Shimodaira, Hidetoshi.

In: Genome Research, Vol. 14, No. 10 A, 10.2004, p. 1832-1850.

Research output: Contribution to journalArticle

Tanaka, M, Cabrera, VM, González, AM, Larruga, JM, Takeyasu, T, Fuku, N, Guo, LJ, Hirose, R, Fujita, Y, Kurata, M, Shinoda, KI, Umetsu, K, Yamada, Y, Oshida, Y, Sato, Y, Hattori, N, Mizuno, Y, Arai, Y, Hirose, N, Ohta, S, Ogawa, O, Tanaka, Y, Kawamori, R, Shamoto-Nagai, M, Maruyama, W, Shimokata, H, Suzuki, R & Shimodaira, H 2004, 'Mitochondrial genome variation in Eastern Asia and the peopling of Japan', Genome Research, vol. 14, no. 10 A, pp. 1832-1850.
Tanaka M, Cabrera VM, González AM, Larruga JM, Takeyasu T, Fuku N et al. Mitochondrial genome variation in Eastern Asia and the peopling of Japan. Genome Research. 2004 Oct;14(10 A):1832-1850.
Tanaka, Masashi ; Cabrera, Vicente M. ; González, Ana M. ; Larruga, José M. ; Takeyasu, Takeshi ; Fuku, Noriyuki ; Guo, Li Jun ; Hirose, Raita ; Fujita, Yasunori ; Kurata, Miyuki ; Shinoda, Ken Ichi ; Umetsu, Kazuo ; Yamada, Yoshiji ; Oshida, Yoshiharu ; Sato, Yuzo ; Hattori, Nobutaka ; Mizuno, Yoshikuni ; Arai, Yasumichi ; Hirose, Nobuyoshi ; Ohta, Shigeo ; Ogawa, Osamu ; Tanaka, Yasushi ; Kawamori, Ryuzo ; Shamoto-Nagai, Masayo ; Maruyama, Wakako ; Shimokata, Hiroshi ; Suzuki, Ryota ; Shimodaira, Hidetoshi. / Mitochondrial genome variation in Eastern Asia and the peopling of Japan. In: Genome Research. 2004 ; Vol. 14, No. 10 A. pp. 1832-1850.
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abstract = "To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the complete mitochondrial genomes of 672 Japanese individuals (http://www.giib.or.jp/mtsnp/index_e.html). This allowed us to perform a phylogenetic analysis with a pool of 942 Asiatic sequences. New clades and subclades emerged from the Japanese data. On the basis of this unequivocal phylogeny, we classified 4713 Asian partial mitochondrial sequences, with <10{\%} ambiguity. Applying population and phylogeographic methods, we used these sequences to shed light on the controversial issue of the peopling of Japan. Population-based comparisons confirmed that present-day Japanese have their closest genetic affinity to northern Asian populations, especially to Koreans, which finding is congruent with the proposed Continental gene flow to Japan after the Yayoi period. This phylogeographic approach unraveled a high degree of differentiation in Paleolithic Japanese. Ancient southern and northern migrations were detected based on the existence of basic M and N lineages in Ryukyuans and Ainu. Direct connections with Tibet, parallel to those found for the Y-chromosome, were also apparent. Furthermore, the highest diversity found in Japan for some derived clades suggests that Japan could be included in an area of migratory expansion to Continental Asia. All the theories that have been proposed up to now to explain the peopling of Japan seem insufficient to accommodate fully this complex picture.",
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AU - Hirose, Raita

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AU - Kurata, Miyuki

AU - Shinoda, Ken Ichi

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AU - Hattori, Nobutaka

AU - Mizuno, Yoshikuni

AU - Arai, Yasumichi

AU - Hirose, Nobuyoshi

AU - Ohta, Shigeo

AU - Ogawa, Osamu

AU - Tanaka, Yasushi

AU - Kawamori, Ryuzo

AU - Shamoto-Nagai, Masayo

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AU - Suzuki, Ryota

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