Mitogenic responses to lipopolysaccharide by B lymphocytes from patients with systemic lupus erythematosus

T. Abe, T. Toguchi, Tsutomu Takeuchi, M. Kiyotaki, M. Homma

Research output: Contribution to journalArticle

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Abstract

Peripheral blood lymphocytes from 43 patients with systemic lupus erythematosus (SLE) and from age- and sex-matched normal controls were cultured with lipopolysaccharide (LPS) to examine the response to the polyclonal B-cell activator. Lymphocytes from active SLE patients incorporated 4840±471 (mean ±SE) cpm in response to LPS, whereas lymphocytes from inactive SLE patients incorporated 6906±897 cpm. In contrast, lymphocytes from normal individuals incorporated 7452±1126 cpm. Ig synthesis of lymphocytes from active SLE in response to LPS stimulation was also less than that of normal individuals. The helper T-cell function of active SLE, as examined by co-culturing irradiated SLE lymphocytes with unirradiated normal lymphocytes, was normal. These results thus suggested that a defect of B lymphocytes exists in active SLE patients. This B-cell defect and T suppressor cells apparently play an important role in the pathogenesis of SLE.

Original languageEnglish
Pages (from-to)475-482
Number of pages8
JournalScandinavian Journal of Immunology
Volume15
Issue number5
DOIs
Publication statusPublished - 1982

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Systemic Lupus Erythematosus
B-Lymphocytes
Lymphocytes
Lipopolysaccharides
lipopolysaccharide B
Helper-Inducer T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Mitogenic responses to lipopolysaccharide by B lymphocytes from patients with systemic lupus erythematosus. / Abe, T.; Toguchi, T.; Takeuchi, Tsutomu; Kiyotaki, M.; Homma, M.

In: Scandinavian Journal of Immunology, Vol. 15, No. 5, 1982, p. 475-482.

Research output: Contribution to journalArticle

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AU - Homma, M.

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