Mixed Infection of Cytomegalovirus and Pulmonary Nocardiosis Caused by Nocardia elegans Diagnosed Using Nanopore Sequencing Technology

Chie Watanabe, Yoshifumi Kimizuka, Yuji Fujikura, Takaaki Hamamoto, Akira Watanabe, Takashi Yaguchi, Tomoya Sano, Ryohei Suematsu, Yoshiki Kato, Jun Miyata, Susumu Matsukuma, Akihiko Kawana

Research output: Contribution to journalArticlepeer-review

Abstract

A 69-year-old woman who had undergone renal transplantation and was receiving sulfamethoxazole/trimethoprim (ST) developed pulmonary nocardiosis. To our knowledge, this is the first report of the identification of Nocardia elegans using nanopore sequencing, supported by 16S rDNA capillary sequencing findings. Chest computed tomography performed after ST initiation revealed significant improvement of the pulmonary shadows compared to previous findings. We herein report the value of nanopore sequencing for rapid identification of rare pathogens, such as Nocardia elegans. Furthermore, our findings suggest that Nocardia may infect even patients receiving ST, which is currently the most effective prophylactic drug.

Original languageEnglish
Pages (from-to)1613-1617
Number of pages5
JournalInternal Medicine
Volume61
Issue number10
DOIs
Publication statusPublished - 2022
Externally publishedYes

Keywords

  • immunocompromised
  • nanopore sequencing
  • nocardiosis
  • organ transplantation

ASJC Scopus subject areas

  • Internal Medicine

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