MK800-62F1, a new inhibitor of apoptotic cell death, from Streptomyces diastatochromogenes MK800-62F1. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity

Yuya Yoshimoto, Tsutomu Sawa, Naoko Kinoshita, Yoshiko Homma, Masa Hamada, Tomio Takeuchi, Masaya Imoto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A new compound, MK800-62F1, was isolated from a cultured broth of Streptomyces diastatochromogenes MK800-62F1. It inhibited H2O2-induced apoptosis in human small cell lung carcinoma Ms-1 cells as well as in human T-cell leukemia Jurkat cells. In addition, MK800-62F1 also inhibited camptothecin-induced apoptosis in Jurkat cells, which was mediated by intracellular H2O2 generation. MK800-62F1 did not exhibit antioxidative activity in vitro, suggesting that inhibition of apoptosis by MK800-62F1 was not due to the scavenging of H2O2, rather it was due to the modulation of the downstream event of H2O2 generation.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalJournal of Antibiotics
Volume53
Issue number6
DOIs
Publication statusPublished - 2000 Jun

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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