MMMDB

Mouse multiple tissue metabolome database

Masahiro Sugimoto, Satsuki Ikeda, Kanako Niigata, Masaru Tomita, Hideyo Sato, Tomoyoshi Soga

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The Mouse Multiple Tissue Metabolome Database (MMMDB) provides comprehensive and quantitative metabolomic information for multiple tissues from single mice. Manually curated databases that integrate literature-based individual metabolite information have been available so far. However, data sets on the absolute concentration of a single metabolite integrated from multiple resources are often difficult to be used when different metabolomic studies are compared because the relative balance of the multiple metabolite concentrations in the metabolic pathways as a snapshot of a dynamic system is more important than the absolute concentration of a single metabolite. We developed MMMDB by performing non-targeted analyses of cerebra, cerebella, thymus, spleen, lung, liver, kidney, heart, pancreas, testis and plasma using capillary electrophoresis time-of-flight mass spectrometry and detected 428 non-redundant features from which 219 metabolites were successfully identified. Quantified concentrations of the individual metabolites and the corresponding processed raw data; for example, the electropherograms and mass spectra with their annotations, such as isotope and fragment information, are stored in the database. MMMDB is designed to normalize users' data, which can be submitted online and used to visualize overlaid electropherograms. Thus, MMMDB allows newly measured data to be compared with the other data in the database. MMMDB is available at: http:// mmmdb.iab.keio.ac.jp.

Original languageEnglish
JournalNucleic Acids Research
Volume40
Issue numberD1
DOIs
Publication statusPublished - 2012 Jan

Fingerprint

Metabolome
Databases
Metabolomics
Capillary Electrophoresis
Cerebrum
Metabolic Networks and Pathways
Isotopes
Cerebellum
Thymus Gland
Testis
Pancreas
Mass Spectrometry
Spleen
Kidney
Lung
Liver

ASJC Scopus subject areas

  • Genetics

Cite this

MMMDB : Mouse multiple tissue metabolome database. / Sugimoto, Masahiro; Ikeda, Satsuki; Niigata, Kanako; Tomita, Masaru; Sato, Hideyo; Soga, Tomoyoshi.

In: Nucleic Acids Research, Vol. 40, No. D1, 01.2012.

Research output: Contribution to journalArticle

Sugimoto, Masahiro ; Ikeda, Satsuki ; Niigata, Kanako ; Tomita, Masaru ; Sato, Hideyo ; Soga, Tomoyoshi. / MMMDB : Mouse multiple tissue metabolome database. In: Nucleic Acids Research. 2012 ; Vol. 40, No. D1.
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