MMP and ADAM in rheumatoid arthritis

Taku Yatabe, Yasunori Okada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Rheumatoid arthritis (RA) is characterized by chronic proliferative synovitis, in which various proteinases are produced and attack the articular cartilage. Among the proteinases, matrix metalloproteinases (MMPs) may play a major role in the degradation of the extracellular matrix macromolecules in RA cartilage. However, recent studies have demonstrated the possible involvement of MMP-related metalloproteinases, i.e. a disintegrin and metalloproteinases (ADAMs) in the degradation. In the present article, we review recent information about the MMP and ADAM families and their implications for cartilage destruction in RA.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalConnective Tissue
Volume36
Issue number4
Publication statusPublished - 2004 Dec

Fingerprint

Disintegrins
Metalloproteases
Matrix Metalloproteinases
Rheumatoid Arthritis
Cartilage
Peptide Hydrolases
Synovitis
Articular Cartilage
Extracellular Matrix

Keywords

  • A disintegrin and metalloproteinase
  • Extracellular matrix
  • Matrix metalloproteinase
  • Rheumatoid arthritis
  • Tissue inhibitor of metalloproteinases

ASJC Scopus subject areas

  • Rheumatology

Cite this

Yatabe, T., & Okada, Y. (2004). MMP and ADAM in rheumatoid arthritis. Connective Tissue, 36(4), 223-231.

MMP and ADAM in rheumatoid arthritis. / Yatabe, Taku; Okada, Yasunori.

In: Connective Tissue, Vol. 36, No. 4, 12.2004, p. 223-231.

Research output: Contribution to journalArticle

Yatabe, T & Okada, Y 2004, 'MMP and ADAM in rheumatoid arthritis', Connective Tissue, vol. 36, no. 4, pp. 223-231.
Yatabe T, Okada Y. MMP and ADAM in rheumatoid arthritis. Connective Tissue. 2004 Dec;36(4):223-231.
Yatabe, Taku ; Okada, Yasunori. / MMP and ADAM in rheumatoid arthritis. In: Connective Tissue. 2004 ; Vol. 36, No. 4. pp. 223-231.
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