Abstract
Parkinson's disease (PD), a common neurodegenerative disorder, is characterized by selective degeneration of dopaminergic neurons in the substantia nigra. There is no effective treatment to delay or halt the progression of PD. The establishment of disease models, based on human biology, is therefore important for developing effective disease-modifying therapies. The recent progress of human induced pluripotent stem cell-associated technologies provides an opportunity to understand disease etiology, discover new drugs, and develop novel therapeutic interventions.
| Original language | English |
|---|---|
| Pages (from-to) | 875-883 |
| Number of pages | 9 |
| Journal | Brain and nerve = Shinkei kenkyu no shinpo |
| Volume | 71 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2019 Aug 1 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Modeling Familial Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells. / Tabata, Yoshikuni; Okano, Hideyuki.
In: Brain and nerve = Shinkei kenkyu no shinpo, Vol. 71, No. 8, 01.08.2019, p. 875-883.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Modeling Familial Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells
AU - Tabata, Yoshikuni
AU - Okano, Hideyuki
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Parkinson's disease (PD), a common neurodegenerative disorder, is characterized by selective degeneration of dopaminergic neurons in the substantia nigra. There is no effective treatment to delay or halt the progression of PD. The establishment of disease models, based on human biology, is therefore important for developing effective disease-modifying therapies. The recent progress of human induced pluripotent stem cell-associated technologies provides an opportunity to understand disease etiology, discover new drugs, and develop novel therapeutic interventions.
AB - Parkinson's disease (PD), a common neurodegenerative disorder, is characterized by selective degeneration of dopaminergic neurons in the substantia nigra. There is no effective treatment to delay or halt the progression of PD. The establishment of disease models, based on human biology, is therefore important for developing effective disease-modifying therapies. The recent progress of human induced pluripotent stem cell-associated technologies provides an opportunity to understand disease etiology, discover new drugs, and develop novel therapeutic interventions.
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UR - http://www.scopus.com/inward/citedby.url?scp=85070635355&partnerID=8YFLogxK
U2 - 10.11477/mf.1416201368
DO - 10.11477/mf.1416201368
M3 - Review article
C2 - 31346144
AN - SCOPUS:85070635355
VL - 71
SP - 875
EP - 883
JO - Brain and Nerve
JF - Brain and Nerve
SN - 0006-8969
IS - 8
ER -