Modeling Familial Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells

Yoshikuni Tabata, Hideyuki Okano

Research output: Contribution to journalReview article

Abstract

Parkinson's disease (PD), a common neurodegenerative disorder, is characterized by selective degeneration of dopaminergic neurons in the substantia nigra. There is no effective treatment to delay or halt the progression of PD. The establishment of disease models, based on human biology, is therefore important for developing effective disease-modifying therapies. The recent progress of human induced pluripotent stem cell-associated technologies provides an opportunity to understand disease etiology, discover new drugs, and develop novel therapeutic interventions.

Original languageEnglish
Pages (from-to)875-883
Number of pages9
JournalBrain and nerve = Shinkei kenkyu no shinpo
Volume71
Issue number8
DOIs
Publication statusPublished - 2019 Aug 1

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Induced Pluripotent Stem Cells
Parkinson Disease
Dopaminergic Neurons
Substantia Nigra
Neurodegenerative Diseases
Therapeutics
Technology
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Modeling Familial Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells. / Tabata, Yoshikuni; Okano, Hideyuki.

In: Brain and nerve = Shinkei kenkyu no shinpo, Vol. 71, No. 8, 01.08.2019, p. 875-883.

Research output: Contribution to journalReview article

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