Modeling neurodevelopment in a dish with pluripotent stem cells

Kent Imaizumi, Hideyuki Okano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Pluripotent stem cells (PSCs) can differentiate into all cell types in the body, and their differentiation procedures recapitulate the developmental processes of embryogenesis. Focusing on neurodevelopment, we describe here the application of knowledge gained from embryology to the neural induction of PSCs. Furthermore, PSC-based neural modeling provides novel insights into neurodevelopmental processes. In particular, human PSC cultures are a powerful tool for the study of human-specific neurodevelopmental processes and could even enable the elucidation of the mechanisms of human brain evolution. We also discuss challenges and potential future directions in further improving PSC-based neural modeling.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalDevelopment Growth and Differentiation
Volume63
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Keywords

  • human-specific neurodevelopment
  • neural specification
  • pluripotent stem cell
  • regional patterning

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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