Modeling phenotypes of malignant gliomas

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Malignant gliomas are primary tumors of the central nervous system characterized by diffuse infiltration into the brain and a high recurrence rate. Advances in comprehensive genomic studies have provided unprecedented insight into the genetic and molecular heterogeneity of these tumors and refined our understanding of their evolution from low to high grade. However, similar levels of phenotypic characterization are indispensable to understanding the complexity of malignant gliomas. Experimental glioma models have also achieved great progress in recent years. Advances in transgenic technologies and cell culture have allowed the establishment of mouse models that mirror the human disease with increasing fidelity and which support single-cell resolution for phenotypic analyses. Here we review the major types of preclinical glioma models, with an emphasis on how recent developments in experimental modeling have shed new light on two fundamental aspects of glioma phenotype, their cell of origin and their invasive potential.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalCancer Science
Volume109
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • experimental model
  • genetically engineered mouse model
  • glioma cell of origin
  • glioma invasion
  • malignant glioma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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