Moderate hypoglycemia induces ultrastructural changes in perivascular nerve terminals of cat cerebral arteries

Kazuo Isozumi, Yasuo Fukuuchi, Atsuo Koto, Norihiro Suzuki, Yoshio Izumi, Yoko Tsuzuki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A quantitative morphological analysis of the perivascular nerve terminals of cerebral arteries during moderate hypoglycemia was performed. 5-Hydroxydopamine (5-OHDA) was applied to discriminate dense-cored vesicles, related to noradrenaline, and clear vesicles, related to acetylcholine, under the electron microscope. Five hypoglycemic and 5 normoglycemic cats, all receiving 5-OHDA, were compared. In both the middle cerebral artery and vertebral artery, the dense-cored vesicles were significantly smaller and clear vesicles were significantly larger in hypoglycemia than in normoglycemia. These morphological changes in the vesicles may indicate hyperactivity of the sympathetic system and hypoactivity of the parasympathetic system of the cerebral vessels during hypoglycemia.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalNeuroscience Letters
Volume134
Issue number1
DOIs
Publication statusPublished - 1991 Dec 16

Keywords

  • Cerebral artery
  • Clear vesicle
  • Dense-cored vesicle
  • Hypoglycemia
  • Parasympathetic system
  • Perivascular nerve terminal
  • Sympathetic system

ASJC Scopus subject areas

  • Neuroscience(all)

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