TY - JOUR
T1 - Moderate hypoglycemia induces ultrastructural changes in perivascular nerve terminals of cat cerebral arteries
AU - Isozumi, Kazuo
AU - Fukuuchi, Yasuo
AU - Koto, Atsuo
AU - Suzuki, Norihiro
AU - Izumi, Yoshio
AU - Tsuzuki, Yoko
PY - 1991/12/16
Y1 - 1991/12/16
N2 - A quantitative morphological analysis of the perivascular nerve terminals of cerebral arteries during moderate hypoglycemia was performed. 5-Hydroxydopamine (5-OHDA) was applied to discriminate dense-cored vesicles, related to noradrenaline, and clear vesicles, related to acetylcholine, under the electron microscope. Five hypoglycemic and 5 normoglycemic cats, all receiving 5-OHDA, were compared. In both the middle cerebral artery and vertebral artery, the dense-cored vesicles were significantly smaller and clear vesicles were significantly larger in hypoglycemia than in normoglycemia. These morphological changes in the vesicles may indicate hyperactivity of the sympathetic system and hypoactivity of the parasympathetic system of the cerebral vessels during hypoglycemia.
AB - A quantitative morphological analysis of the perivascular nerve terminals of cerebral arteries during moderate hypoglycemia was performed. 5-Hydroxydopamine (5-OHDA) was applied to discriminate dense-cored vesicles, related to noradrenaline, and clear vesicles, related to acetylcholine, under the electron microscope. Five hypoglycemic and 5 normoglycemic cats, all receiving 5-OHDA, were compared. In both the middle cerebral artery and vertebral artery, the dense-cored vesicles were significantly smaller and clear vesicles were significantly larger in hypoglycemia than in normoglycemia. These morphological changes in the vesicles may indicate hyperactivity of the sympathetic system and hypoactivity of the parasympathetic system of the cerebral vessels during hypoglycemia.
KW - Cerebral artery
KW - Clear vesicle
KW - Dense-cored vesicle
KW - Hypoglycemia
KW - Parasympathetic system
KW - Perivascular nerve terminal
KW - Sympathetic system
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U2 - 10.1016/0304-3940(91)90510-Z
DO - 10.1016/0304-3940(91)90510-Z
M3 - Article
C2 - 1815151
AN - SCOPUS:0026340672
SN - 0304-3940
VL - 134
SP - 67
EP - 70
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -