Modification of cardiac phenotype in Tbx1 hypomorphic mice

Takatoshi Tsuchihashi, Reina Ishizaki, Jun Maeda, Akimichi Shibata, Keiko Uchida, Deepak Srivastava, Hiroyuki Yamagishi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Congenital heart disease is still the leading cause of death within the first year of life. Our lab forces on understanding the morphology of congenital heart disease. Outflow tract anomalies, including abnormal alignment or septation, account for 30 % of all congenital heart disease. To solve the developmental problem of these defects, we are interested in the role of the second heart field (SHF) that gives rise to the outflow tract structure.

Original languageEnglish
Title of host publicationEtiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology
PublisherSpringer Japan
Pages215-217
Number of pages3
ISBN (Electronic)9784431546283
ISBN (Print)9784431546276
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Environmental modification
  • Tbx1
  • Truncus arteriosus

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Tsuchihashi, T., Ishizaki, R., Maeda, J., Shibata, A., Uchida, K., Srivastava, D., & Yamagishi, H. (2016). Modification of cardiac phenotype in Tbx1 hypomorphic mice. In Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology (pp. 215-217). Springer Japan. https://doi.org/10.1007/978-4-431-54628-3_28