Modification of Cellular Membrane Functions by Pendolmycin

Kazuo Umezawa; Masaya Imoto; Takashi Yamashita; Tsutomu Sawa; Tomio Takeuchi

doi:10.1111/j.1349-7006.1989.tb02238.x

Modification of Cellular Membrane Functions by Pendolmycin

Kazuo Umezawa, Masaya Imoto, Takashi Yamashita, Tsutomu Sawa, Tomio Takeuchi

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Japanese Journal of Cancer Research
Volume	80
Issue number	1
DOIs	https://doi.org/10.1111/j.1349-7006.1989.tb02238.x
Publication status	Published - 1989 Jan

Keywords

Epidermal growth factor
Pendolmycin
Phosphatidylinositol turnover
Teleocidin
Tumor promotion

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.",

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author = "Kazuo Umezawa and Masaya Imoto and Takashi Yamashita and Tsutomu Sawa and Tomio Takeuchi",

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AU - Umezawa, Kazuo

AU - Imoto, Masaya

AU - Yamashita, Takashi

AU - Sawa, Tsutomu

AU - Takeuchi, Tomio

PY - 1989/1

Y1 - 1989/1

N2 - Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.

AB - Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.

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KW - Phosphatidylinositol turnover

KW - Teleocidin

KW - Tumor promotion

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Modification of Cellular Membrane Functions by Pendolmycin

Abstract

Keywords

ASJC Scopus subject areas

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