Modification of Cellular Membrane Functions by Pendolmycin

Kazuo Umezawa; Masaya Imoto; Takashi Yamashita; Tsutomu Sawa; Tomio Takeuchi

doi:10.1111/j.1349-7006.1989.tb02238.x

Modification of Cellular Membrane Functions by Pendolmycin

Kazuo Umezawa, Masaya Imoto, Takashi Yamashita, Tsutomu Sawa, Tomio Takeuchi

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Japanese Journal of Cancer Research
Volume	80
Issue number	1
DOIs	https://doi.org/10.1111/j.1349-7006.1989.tb02238.x
Publication status	Published - 1989 Jan

Keywords

Epidermal growth factor
Pendolmycin
Phosphatidylinositol turnover
Teleocidin
Tumor promotion

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1989.tb02238.x

Cite this

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title = "Modification of Cellular Membrane Functions by Pendolmycin",

abstract = "Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.",

keywords = "Epidermal growth factor, Pendolmycin, Phosphatidylinositol turnover, Teleocidin, Tumor promotion",

author = "Kazuo Umezawa and Masaya Imoto and Takashi Yamashita and Tsutomu Sawa and Tomio Takeuchi",

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T1 - Modification of Cellular Membrane Functions by Pendolmycin

AU - Umezawa, Kazuo

AU - Imoto, Masaya

AU - Yamashita, Takashi

AU - Sawa, Tsutomu

AU - Takeuchi, Tomio

PY - 1989/1

Y1 - 1989/1

N2 - Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.

AB - Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.

KW - Epidermal growth factor

KW - Pendolmycin

KW - Phosphatidylinositol turnover

KW - Teleocidin

KW - Tumor promotion

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ER -

Modification of Cellular Membrane Functions by Pendolmycin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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