Modification of Cellular Membrane Functions by Pendolmycin

Kazuo Umezawa, Masaya Imoto, Takashi Yamashita, Tsutomu Sawa, Tomio Takeuchi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalJapanese Journal of Cancer Research
Volume80
Issue number1
DOIs
Publication statusPublished - 1989 Jan
Externally publishedYes

Keywords

  • Epidermal growth factor
  • Pendolmycin
  • Phosphatidylinositol turnover
  • Teleocidin
  • Tumor promotion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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