Abstract
Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidyl‐inositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12‐O‐tetradecanoylphorbol‐13‐acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated ara‐chidonic acid release and hexose transport, and inhibited binding of phorbol‐12,13‐tlibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.
| Original language | English |
|---|---|
| Pages (from-to) | 15-18 |
| Number of pages | 4 |
| Journal | Japanese Journal of Cancer Research |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1989 Jan |
| Externally published | Yes |
Keywords
- Epidermal growth factor
- Pendolmycin
- Phosphatidylinositol turnover
- Teleocidin
- Tumor promotion
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Umezawa, K., Imoto, M., Yamashita, T., Sawa, T., & Takeuchi, T. (1989). Modification of Cellular Membrane Functions by Pendolmycin. Japanese Journal of Cancer Research, 80(1), 15-18. https://doi.org/10.1111/j.1349-7006.1989.tb02238.x