Modulating the catalytic activity and the substrate specificity of alcohol dehydrogenases using cyclic ethers

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The catalytic activities of alcohol dehydrogenases (ADHs) are investigated in the presence of 5% cyclic ethers. Although most cyclic ethers show an inhibitory effect on ADHs, we found that the catalytic rate constant of 2-butanol oxidation by Thermoanaerobacter brockii ADH was increased from 57 to 190 min<sup>-1</sup> by the addition of 1,3-dioxolane, which altered the substrate specificity.

Original languageEnglish
Pages (from-to)3922-3925
Number of pages4
JournalCatalysis Science and Technology
Issue number8
Publication statusPublished - 2015 Aug 1


ASJC Scopus subject areas

  • Catalysis

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