Modulatory role of vasopressin in secretion of atrial natriuretic polypeptide in conscious rats

Hiroshi Itoh; Kazuwa Nakao; Takayuki Yamada; Narito Morii; Shozo Shiono; Akira Sugawara; Yoshihiko Saito; Masashi Mukoyama; Hiroshi Arai; Goro Katsuura; Nasami Eigyo; Akira Matsushita; Hiroo Imura

doi:10.1210/endo-120-5-2186

Modulatory role of vasopressin in secretion of atrial natriuretic polypeptide in conscious rats

Hiroshi Itoh, Kazuwa Nakao, Takayuki Yamada, Narito Morii, Shozo Shiono, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Goro Katsuura, Nasami Eigyo, Akira Matsushita, Hiroo Imura

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate whether vasopressin is involved in the secretory mechanism of atrial natriuretic polypeptide (ANP), effects of arginine-vasopressin (AVP) administered iv on plasma ANP levels were studied in conscious, unrestrained rats. The administration of 100 ng and 1 ug of AVP caused a dose-dependent increase of the plasma ANP level, which was blocked by a V1-receptor antagonist of AVP, and was attenuated by 5 ml blood volume reduction before the stimulation. The injection of less than 10 ng of AVP induced no significant effects on ANP secretion. However, the administration of 5 ng of AVP significantly enhanced ANP secretion induced by intravascular volume expansion with 3 ml saline infusion. These results suggest the possible physiological significance of AVP as a modulator rather than a direct stimulator of ANP secretion from the heart.

Original language	English
Pages (from-to)	2186-2188
Number of pages	3
Journal	Endocrinology
Volume	120
Issue number	5
DOIs	https://doi.org/10.1210/endo-120-5-2186
Publication status	Published - 1987 May
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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title = "Modulatory role of vasopressin in secretion of atrial natriuretic polypeptide in conscious rats",

abstract = "To investigate whether vasopressin is involved in the secretory mechanism of atrial natriuretic polypeptide (ANP), effects of arginine-vasopressin (AVP) administered iv on plasma ANP levels were studied in conscious, unrestrained rats. The administration of 100 ng and 1 ug of AVP caused a dose-dependent increase of the plasma ANP level, which was blocked by a V1-receptor antagonist of AVP, and was attenuated by 5 ml blood volume reduction before the stimulation. The injection of less than 10 ng of AVP induced no significant effects on ANP secretion. However, the administration of 5 ng of AVP significantly enhanced ANP secretion induced by intravascular volume expansion with 3 ml saline infusion. These results suggest the possible physiological significance of AVP as a modulator rather than a direct stimulator of ANP secretion from the heart.",

author = "Hiroshi Itoh and Kazuwa Nakao and Takayuki Yamada and Narito Morii and Shozo Shiono and Akira Sugawara and Yoshihiko Saito and Masashi Mukoyama and Hiroshi Arai and Goro Katsuura and Nasami Eigyo and Akira Matsushita and Hiroo Imura",

year = "1987",

month = may,

doi = "10.1210/endo-120-5-2186",

language = "English",

volume = "120",

pages = "2186--2188",

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T1 - Modulatory role of vasopressin in secretion of atrial natriuretic polypeptide in conscious rats

AU - Itoh, Hiroshi

AU - Nakao, Kazuwa

AU - Yamada, Takayuki

AU - Morii, Narito

AU - Shiono, Shozo

AU - Sugawara, Akira

AU - Saito, Yoshihiko

AU - Mukoyama, Masashi

AU - Arai, Hiroshi

AU - Katsuura, Goro

AU - Eigyo, Nasami

AU - Matsushita, Akira

AU - Imura, Hiroo

PY - 1987/5

Y1 - 1987/5

N2 - To investigate whether vasopressin is involved in the secretory mechanism of atrial natriuretic polypeptide (ANP), effects of arginine-vasopressin (AVP) administered iv on plasma ANP levels were studied in conscious, unrestrained rats. The administration of 100 ng and 1 ug of AVP caused a dose-dependent increase of the plasma ANP level, which was blocked by a V1-receptor antagonist of AVP, and was attenuated by 5 ml blood volume reduction before the stimulation. The injection of less than 10 ng of AVP induced no significant effects on ANP secretion. However, the administration of 5 ng of AVP significantly enhanced ANP secretion induced by intravascular volume expansion with 3 ml saline infusion. These results suggest the possible physiological significance of AVP as a modulator rather than a direct stimulator of ANP secretion from the heart.

AB - To investigate whether vasopressin is involved in the secretory mechanism of atrial natriuretic polypeptide (ANP), effects of arginine-vasopressin (AVP) administered iv on plasma ANP levels were studied in conscious, unrestrained rats. The administration of 100 ng and 1 ug of AVP caused a dose-dependent increase of the plasma ANP level, which was blocked by a V1-receptor antagonist of AVP, and was attenuated by 5 ml blood volume reduction before the stimulation. The injection of less than 10 ng of AVP induced no significant effects on ANP secretion. However, the administration of 5 ng of AVP significantly enhanced ANP secretion induced by intravascular volume expansion with 3 ml saline infusion. These results suggest the possible physiological significance of AVP as a modulator rather than a direct stimulator of ANP secretion from the heart.

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JF - Endocrinology

IS - 5

ER -

Modulatory role of vasopressin in secretion of atrial natriuretic polypeptide in conscious rats

Abstract

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