Molecular analysis of the h-warts/LATS1 gene in human breast cancer.

N. Morinaga, Y. Shitara, Y. Yanagita, T. Koida, M. Kimura, T. Asao, I. Kimijima, S. Takenoshita, T. Hirota, H. Saya, H. Kuwano

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25 Citations (Scopus)

Abstract

Loss of heterozygosity (LOH) on chromosome 6q is often observed in breast cancer, suggesting the existence of a putative tumor suppressor. Recently, a human homolog of the Drosophila warts tumor suppressor gene, h-warts/LATS1, was identified and mapped at chromosome 6q24-25.1. Mutation analysis of the h-warts/LATS1 was performed using 25 breast cancer tissues by RT-PCR SSCP analysis. Although LOH of the h-warts/LATS1 was found in one patient, no mutations were found. Two polymorphisms were found, but neither of them caused amino acid substitutions. Further investigations are necessary to elucidate the role of the h-warts/LATS1 gene in the carcinogenesis of breast cancer.

Original languageEnglish
Pages (from-to)1125-1129
Number of pages5
JournalInternational journal of oncology
Volume17
Issue number6
Publication statusPublished - 2000 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Morinaga, N., Shitara, Y., Yanagita, Y., Koida, T., Kimura, M., Asao, T., Kimijima, I., Takenoshita, S., Hirota, T., Saya, H., & Kuwano, H. (2000). Molecular analysis of the h-warts/LATS1 gene in human breast cancer. International journal of oncology, 17(6), 1125-1129.