TY - JOUR
T1 - Molecular and Cellular Regulations in the Development of the Choroidal Circulation System
AU - Imanishi, Satoshi
AU - Tomita, Yohei
AU - Negishi, Kazuno
AU - Tsubota, Kazuo
AU - Kurihara, Toshihide
N1 - Funding Information:
This work was funded by the Japan Agency for Medical Research and Development (AMED) under Grant Number JP22gm1510007 to T.K. This work was also supported by research grants from the Japanese Retinitis Pigmentosa Society Public Interest Incorporated Association to Y.T. and a grant for Myopia Research from Tsubota Laboratory, Inc. (Tokyo, Japan).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - Disorders in the development and regulation of blood vessels are involved in various ocular disorders, such as persistent hyperplastic primary vitreous, familial exudative vitreoretinopathy, and choroidal dystrophy. Thus, the appropriate regulation of vascular development is essential for healthy ocular functions. However, regulation of the developing choroidal circulation system has not been well studied compared with vascular regulation in the vitreous and the retina. The choroid is a vascular-rich and uniquely structured tissue supplying oxygen and nutrients to the retina, and hypoplasia and the degeneration of the choroid are involved in many ocular disorders. Therefore, understanding the developing choroidal circulation system expands our knowledge of ocular development and supports our understanding of ocular disorders. In this review, we examine studies on regulating the developing choroidal circulation system at the cellular and molecular levels and discuss the relevance to human diseases.
AB - Disorders in the development and regulation of blood vessels are involved in various ocular disorders, such as persistent hyperplastic primary vitreous, familial exudative vitreoretinopathy, and choroidal dystrophy. Thus, the appropriate regulation of vascular development is essential for healthy ocular functions. However, regulation of the developing choroidal circulation system has not been well studied compared with vascular regulation in the vitreous and the retina. The choroid is a vascular-rich and uniquely structured tissue supplying oxygen and nutrients to the retina, and hypoplasia and the degeneration of the choroid are involved in many ocular disorders. Therefore, understanding the developing choroidal circulation system expands our knowledge of ocular development and supports our understanding of ocular disorders. In this review, we examine studies on regulating the developing choroidal circulation system at the cellular and molecular levels and discuss the relevance to human diseases.
KW - choroidal development
KW - ocular disorders
KW - vascular development
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U2 - 10.3390/ijms24065371
DO - 10.3390/ijms24065371
M3 - Review article
C2 - 36982446
AN - SCOPUS:85151108816
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 6
M1 - 5371
ER -
