Molecular approach to uterine leiomyosarcoma

LMP2-deficient mice as an animal model of spontaneous uterine leiomyosarcoma

Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Nobuyoshi Hiraoka, Yae Kanai, Tanri Shiozawa, Susumu Tonegawa, Ikuo Konishi

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40 by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach.

Original languageEnglish
Article number476498
JournalSarcoma
Volume2011
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Leiomyosarcoma
Animal Models
Leiomyoma
Biomarkers
Cervix Uteri
Neoplasms
Hormones
Muscles

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Molecular approach to uterine leiomyosarcoma : LMP2-deficient mice as an animal model of spontaneous uterine leiomyosarcoma. / Hayashi, Takuma; Horiuchi, Akiko; Sano, Kenji; Hiraoka, Nobuyoshi; Kanai, Yae; Shiozawa, Tanri; Tonegawa, Susumu; Konishi, Ikuo.

In: Sarcoma, Vol. 2011, 476498, 2011.

Research output: Contribution to journalReview article

Hayashi, Takuma ; Horiuchi, Akiko ; Sano, Kenji ; Hiraoka, Nobuyoshi ; Kanai, Yae ; Shiozawa, Tanri ; Tonegawa, Susumu ; Konishi, Ikuo. / Molecular approach to uterine leiomyosarcoma : LMP2-deficient mice as an animal model of spontaneous uterine leiomyosarcoma. In: Sarcoma. 2011 ; Vol. 2011.
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abstract = "Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40 by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach.",
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AU - Hayashi, Takuma

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AU - Sano, Kenji

AU - Hiraoka, Nobuyoshi

AU - Kanai, Yae

AU - Shiozawa, Tanri

AU - Tonegawa, Susumu

AU - Konishi, Ikuo

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