Molecular approaches and modern clinical strategies for the management of Helicobacter pylori infection in Japan

Hidekazu Suzuki, Toshihiro Nishizawa, Hitoshi Tsugawa, Toshifumi Hibi

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Thirty years have passed since Warren and Marshall's discovery of Helicobacter pylori (H. pylori). Since then, not only peptic ulcer diseases and chronic gastritis but also non-cardia gastric cancers have been recognized as diseases originating from H. pylori infection. Several combination therapies consisting of multiple antibiotics have been developed as first- or second-line regimens to eradicate H. pylori infection. Our extensive experience in the field of anti-H. pylori medicine suggests that clinicians should consider a possible role for unidentified, invisible pathogens to elucidate the pathogenesis and improve the treatment of refractory diseases of unknown etiology.

Original languageEnglish
Pages (from-to)109-119
Number of pages11
JournalKeio Journal of Medicine
Volume61
Issue number4
DOIs
Publication statusPublished - 2012 Dec 1

Keywords

  • CagA
  • Diagnosis
  • Eradication
  • Helicobacter pylori
  • Indication

ASJC Scopus subject areas

  • Medicine(all)

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