Molecular aspects of rheumatoid arthritis: Chemokines in the joints of patients

Takuji Iwamoto, Hiroshi Okamoto, Yoshiaki Toyama, Shigeki Momohara

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone. In RA synovial tissue, the infiltrating cells such as macrophages, T cells, B cells and dendritic cells play important role in the pathogenesis of RA. Migration of leukocytes into the synovium is a regulated multi-step process, involving interactions between leukocytes and endothelial cells, cellular adhesion molecules, as well as chemokines and chemokine receptors. Chemokines are small, chemoattractant cytokines which play key roles in the accumulation of inflammatory cells at the site of inflammation. It is known that synovial tissue and synovial fluid from RA patients contain increased concentrations of several chemokines, such as monocyte chemoattractant protein-4 (MCP-4)/CCL13, pulmonary and activation-regulated chemokine (PARC)/CCL18, monokine induced by interferon-γ (Mig)/CXCL9, stromal cell-derived factor 1 (SDF-1)/CXCL12, monocyte chemotactic protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 1α (MIP-1α)/CCL3, and Fractalkine/CXC3CL1. Therefore, chemokines and chemokine-receptors are considered to be important molecules in RA pathology.

Original languageEnglish
Pages (from-to)4448-4455
Number of pages8
JournalFEBS Journal
Volume275
Issue number18
DOIs
Publication statusPublished - 2008 Sep

Fingerprint

Chemokines
Rheumatoid Arthritis
Joints
Chemokine Receptors
Monocyte Chemoattractant Proteins
Leukocytes
Foot Joints
Chemokine CX3CL1
Cells
Hand Joints
Monokines
Tissue
Macrophage Inflammatory Proteins
Chemokine CXCL12
Molecules
T-cells
Synovial Membrane
Joint Diseases
Chemokine CCL2
Macrophages

Keywords

  • Chemokine receptors
  • Chemokines
  • Monocyte chemoattractant protein-4 (MCP-4)/CCL13
  • Pulmonary and activation-regulated chemokine (PARC)/CCL18
  • Rheumatoid arthritis (RA)

ASJC Scopus subject areas

  • Biochemistry

Cite this

Molecular aspects of rheumatoid arthritis : Chemokines in the joints of patients. / Iwamoto, Takuji; Okamoto, Hiroshi; Toyama, Yoshiaki; Momohara, Shigeki.

In: FEBS Journal, Vol. 275, No. 18, 09.2008, p. 4448-4455.

Research output: Contribution to journalArticle

Iwamoto, Takuji ; Okamoto, Hiroshi ; Toyama, Yoshiaki ; Momohara, Shigeki. / Molecular aspects of rheumatoid arthritis : Chemokines in the joints of patients. In: FEBS Journal. 2008 ; Vol. 275, No. 18. pp. 4448-4455.
@article{562560d5524e4aabb1085ddf8c84cb26,
title = "Molecular aspects of rheumatoid arthritis: Chemokines in the joints of patients",
abstract = "Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone. In RA synovial tissue, the infiltrating cells such as macrophages, T cells, B cells and dendritic cells play important role in the pathogenesis of RA. Migration of leukocytes into the synovium is a regulated multi-step process, involving interactions between leukocytes and endothelial cells, cellular adhesion molecules, as well as chemokines and chemokine receptors. Chemokines are small, chemoattractant cytokines which play key roles in the accumulation of inflammatory cells at the site of inflammation. It is known that synovial tissue and synovial fluid from RA patients contain increased concentrations of several chemokines, such as monocyte chemoattractant protein-4 (MCP-4)/CCL13, pulmonary and activation-regulated chemokine (PARC)/CCL18, monokine induced by interferon-γ (Mig)/CXCL9, stromal cell-derived factor 1 (SDF-1)/CXCL12, monocyte chemotactic protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 1α (MIP-1α)/CCL3, and Fractalkine/CXC3CL1. Therefore, chemokines and chemokine-receptors are considered to be important molecules in RA pathology.",
keywords = "Chemokine receptors, Chemokines, Monocyte chemoattractant protein-4 (MCP-4)/CCL13, Pulmonary and activation-regulated chemokine (PARC)/CCL18, Rheumatoid arthritis (RA)",
author = "Takuji Iwamoto and Hiroshi Okamoto and Yoshiaki Toyama and Shigeki Momohara",
year = "2008",
month = "9",
doi = "10.1111/j.1742-4658.2008.06580.x",
language = "English",
volume = "275",
pages = "4448--4455",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",
number = "18",

}

TY - JOUR

T1 - Molecular aspects of rheumatoid arthritis

T2 - Chemokines in the joints of patients

AU - Iwamoto, Takuji

AU - Okamoto, Hiroshi

AU - Toyama, Yoshiaki

AU - Momohara, Shigeki

PY - 2008/9

Y1 - 2008/9

N2 - Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone. In RA synovial tissue, the infiltrating cells such as macrophages, T cells, B cells and dendritic cells play important role in the pathogenesis of RA. Migration of leukocytes into the synovium is a regulated multi-step process, involving interactions between leukocytes and endothelial cells, cellular adhesion molecules, as well as chemokines and chemokine receptors. Chemokines are small, chemoattractant cytokines which play key roles in the accumulation of inflammatory cells at the site of inflammation. It is known that synovial tissue and synovial fluid from RA patients contain increased concentrations of several chemokines, such as monocyte chemoattractant protein-4 (MCP-4)/CCL13, pulmonary and activation-regulated chemokine (PARC)/CCL18, monokine induced by interferon-γ (Mig)/CXCL9, stromal cell-derived factor 1 (SDF-1)/CXCL12, monocyte chemotactic protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 1α (MIP-1α)/CCL3, and Fractalkine/CXC3CL1. Therefore, chemokines and chemokine-receptors are considered to be important molecules in RA pathology.

AB - Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone. In RA synovial tissue, the infiltrating cells such as macrophages, T cells, B cells and dendritic cells play important role in the pathogenesis of RA. Migration of leukocytes into the synovium is a regulated multi-step process, involving interactions between leukocytes and endothelial cells, cellular adhesion molecules, as well as chemokines and chemokine receptors. Chemokines are small, chemoattractant cytokines which play key roles in the accumulation of inflammatory cells at the site of inflammation. It is known that synovial tissue and synovial fluid from RA patients contain increased concentrations of several chemokines, such as monocyte chemoattractant protein-4 (MCP-4)/CCL13, pulmonary and activation-regulated chemokine (PARC)/CCL18, monokine induced by interferon-γ (Mig)/CXCL9, stromal cell-derived factor 1 (SDF-1)/CXCL12, monocyte chemotactic protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 1α (MIP-1α)/CCL3, and Fractalkine/CXC3CL1. Therefore, chemokines and chemokine-receptors are considered to be important molecules in RA pathology.

KW - Chemokine receptors

KW - Chemokines

KW - Monocyte chemoattractant protein-4 (MCP-4)/CCL13

KW - Pulmonary and activation-regulated chemokine (PARC)/CCL18

KW - Rheumatoid arthritis (RA)

UR - http://www.scopus.com/inward/record.url?scp=50849144863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50849144863&partnerID=8YFLogxK

U2 - 10.1111/j.1742-4658.2008.06580.x

DO - 10.1111/j.1742-4658.2008.06580.x

M3 - Article

C2 - 18662305

AN - SCOPUS:50849144863

VL - 275

SP - 4448

EP - 4455

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

IS - 18

ER -