Molecular aspects of rheumatoid arthritis: Chemokines in the joints of patients

Takuji Iwamoto, Hiroshi Okamoto, Yoshiaki Toyama, Shigeki Momohara

Research output: Contribution to journalShort survey

164 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone. In RA synovial tissue, the infiltrating cells such as macrophages, T cells, B cells and dendritic cells play important role in the pathogenesis of RA. Migration of leukocytes into the synovium is a regulated multi-step process, involving interactions between leukocytes and endothelial cells, cellular adhesion molecules, as well as chemokines and chemokine receptors. Chemokines are small, chemoattractant cytokines which play key roles in the accumulation of inflammatory cells at the site of inflammation. It is known that synovial tissue and synovial fluid from RA patients contain increased concentrations of several chemokines, such as monocyte chemoattractant protein-4 (MCP-4)/CCL13, pulmonary and activation-regulated chemokine (PARC)/CCL18, monokine induced by interferon-γ (Mig)/CXCL9, stromal cell-derived factor 1 (SDF-1)/CXCL12, monocyte chemotactic protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 1α (MIP-1α)/CCL3, and Fractalkine/CXC3CL1. Therefore, chemokines and chemokine-receptors are considered to be important molecules in RA pathology.

Original languageEnglish
Pages (from-to)4448-4455
Number of pages8
JournalFEBS Journal
Volume275
Issue number18
DOIs
Publication statusPublished - 2008 Sep 1

Keywords

  • Chemokine receptors
  • Chemokines
  • Monocyte chemoattractant protein-4 (MCP-4)/CCL13
  • Pulmonary and activation-regulated chemokine (PARC)/CCL18
  • Rheumatoid arthritis (RA)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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