Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis

Kenya Honda, Hiroyasu Nakano, Hisahiro Yoshida, Satomi Nishikawa, Paul Rennert, Koichi Ikuta, Masakatsu Tamechika, Kazuhito Yamaguchi, Tetsuo Fukumoto, Tsutomu Chiba, Shin Ichi Nishikawa

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

Mice deficient in lymphotoxin β receptor (LTβR) or interleukin 7 receptor α (IL-7Rα) lack Peyer's patches (PPs). Deficiency in CXC chemokine receptor 5 (CXCR5) also severely affects the development of PPs. A molecular network involving these three signaling pathways has been implicated in PP organogenesis, but it remains unclear how they are connected during this process. We have shown that PP organogenesis is initiated at sites containing IL-7Rα+ lymphoid cells and vascular cell adhesion molecule (VCAM)-1/intercellular adhesion molecule (ICAM)-1 expressing nonlymphoid elements. Here we characterize these lymphoid and non-lymphoid components in terms of chemokine signals. The lymphoid population expresses CXCR5 and has a strong chemotactic response to B lymphocyte chemoattractant (BLC). Importantly, chemokines produced by VCAM-1+ICAM-1+ nonlymphoid cells mediate the recruitment of lymphoid cells. Furthermore, we show that these VCAM-1+ICAM-1+ cells are mesenchymal cells that are activated by lymphoid cells through the LTβR to express adhesion molecules and chemokines. Thus, promotion of PP development relies on mutual interaction between mesenchymal and lymphoid cells.

Original languageEnglish
Pages (from-to)621-630
Number of pages10
JournalJournal of Experimental Medicine
Volume193
Issue number5
DOIs
Publication statusPublished - 2001 Mar 5
Externally publishedYes

Fingerprint

Peyer's Patches
Organogenesis
CXCR5 Receptors
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Interleukin-7 Receptors
Chemokines
Lymphocytes
Lymphotoxin-alpha
Chemotactic Factors
B-Lymphocytes
Population

Keywords

  • Chemokines
  • Chemotaxis
  • Interleukin 7
  • Lymphoid tissue
  • Lymphotoxin

ASJC Scopus subject areas

  • Immunology

Cite this

Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. / Honda, Kenya; Nakano, Hiroyasu; Yoshida, Hisahiro; Nishikawa, Satomi; Rennert, Paul; Ikuta, Koichi; Tamechika, Masakatsu; Yamaguchi, Kazuhito; Fukumoto, Tetsuo; Chiba, Tsutomu; Nishikawa, Shin Ichi.

In: Journal of Experimental Medicine, Vol. 193, No. 5, 05.03.2001, p. 621-630.

Research output: Contribution to journalArticle

Honda, K, Nakano, H, Yoshida, H, Nishikawa, S, Rennert, P, Ikuta, K, Tamechika, M, Yamaguchi, K, Fukumoto, T, Chiba, T & Nishikawa, SI 2001, 'Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis', Journal of Experimental Medicine, vol. 193, no. 5, pp. 621-630. https://doi.org/10.1084/jem.193.5.621
Honda, Kenya ; Nakano, Hiroyasu ; Yoshida, Hisahiro ; Nishikawa, Satomi ; Rennert, Paul ; Ikuta, Koichi ; Tamechika, Masakatsu ; Yamaguchi, Kazuhito ; Fukumoto, Tetsuo ; Chiba, Tsutomu ; Nishikawa, Shin Ichi. / Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. In: Journal of Experimental Medicine. 2001 ; Vol. 193, No. 5. pp. 621-630.
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