Molecular biology and pharmacology of natriuretic peptide system

Hiroshi Itoh, S. Suga, Y. Ogawa, I. Tanaka, K. Nakao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The natriuretic peptide system comprises at least three endogenous ligands, namely, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and three receptors for natriuretic peptides (NPR), that is, NPR-A, NPR-B and clearance receptor (NPR-C). Three natriuretic peptides derived from the distinct genes share a common ring structure with 17 amino acids formed by a disulfide linkage which confers the unique biological property on these peptides. ANP and BNP are elucidated to be the cardiac hormone mainly secreted from the atrium, and from the ventricle, respectively. CNP, first recognized as the neuropeptide, is now identified within the vascular wall, especially in endothelial cells and considered to be the peptidic endothelium-derived relaxing factor (EDRF). While NPR-A shows the high affinity to ANP and BNP, NPR-B is the selective receptor for CNP. These two types of "biologically active" NPR are the membrane-bound guanylate cyclase itself, and mediate the wide range of biological actions of natriuretic peptides through cyclic GMP-dependent cascade. The clearance receptor shows the ligand-binding affinity with the rank order of ANP > CNP > BNP and is considered to be involved in the clearance of the peptides. The natriuretic peptide system as an endocrine and paracrine/autocrine system serves as one of the key modulatory systems for blood pressure, body fluid homeostasis and vascular remodeling.

Original languageEnglish
Pages (from-to)1548-1556
Number of pages9
JournalNippon rinsho. Japanese journal of clinical medicine
Volume51
Issue number6
Publication statusPublished - 1993 Jun
Externally publishedYes

Fingerprint

Natriuretic Peptides
C-Type Natriuretic Peptide
Brain Natriuretic Peptide
Atrial Natriuretic Factor
Molecular Biology
Pharmacology
Ligands
Endothelium-Dependent Relaxing Factors
Peptides
Endocrine System
Guanylate Cyclase
Cyclic GMP
Body Fluids
Neuropeptides
Disulfides
Blood Vessels
Homeostasis
Endothelial Cells
Hormones
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Molecular biology and pharmacology of natriuretic peptide system. / Itoh, Hiroshi; Suga, S.; Ogawa, Y.; Tanaka, I.; Nakao, K.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 51, No. 6, 06.1993, p. 1548-1556.

Research output: Contribution to journalArticle

Itoh, H, Suga, S, Ogawa, Y, Tanaka, I & Nakao, K 1993, 'Molecular biology and pharmacology of natriuretic peptide system', Nippon rinsho. Japanese journal of clinical medicine, vol. 51, no. 6, pp. 1548-1556.
Itoh, Hiroshi ; Suga, S. ; Ogawa, Y. ; Tanaka, I. ; Nakao, K. / Molecular biology and pharmacology of natriuretic peptide system. In: Nippon rinsho. Japanese journal of clinical medicine. 1993 ; Vol. 51, No. 6. pp. 1548-1556.
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