Molecular biology of glioma

Tomotoshi Marumoto, Hideyuki Saya

Research output: Chapter in Book/Report/Conference proceedingChapter

52 Citations (Scopus)

Abstract

Glioblastoma (GBM) is the most aggressive form of glioma. Despite ceaseless efforts by researchers and physicians to find new therapeutic strategies, there have been no significant advances in the treatment of GBMs for several decades and most patients with GBM die within one and half years of diagnosis. Undoubtedly, one reason for this is the insufficient understanding of the initiation and progression of GBMs at the molecular level. However, recent information regarding the genetic and epigenetic alterations and the microRNAs that are aberrantly activated or inactivated in GBMs has helped elucidate the formation of GBM in more detail. Here, we describe recent advances in the understanding of the biology of GBMs.

Original languageEnglish
Title of host publicationGlioma
Subtitle of host publicationImmunotherapeutic Approaches
EditorsRyuya Yamanaka
Pages2-11
Number of pages10
DOIs
Publication statusPublished - 2012 Jul 3

Publication series

NameAdvances in Experimental Medicine and Biology
Volume746
ISSN (Print)0065-2598

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Marumoto, T., & Saya, H. (2012). Molecular biology of glioma. In R. Yamanaka (Ed.), Glioma: Immunotherapeutic Approaches (pp. 2-11). (Advances in Experimental Medicine and Biology; Vol. 746). https://doi.org/10.1007/978-1-4614-3146-6_1